Entity Details

Primary name PTEN_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08586
EntryNamePTEN_MOUSE
FullNamePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
TaxID10090
Evidenceevidence at protein level
Length403
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPten

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002902 regulation of B cell apoptotic process
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0006915 apoptotic process
GO:0007270 neuron-neuron synaptic transmission
GO:0007416 synapse assembly
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009749 response to glucose
GO:0009898 cytoplasmic side of plasma membrane
GO:0010043 response to zinc ion
GO:0010628 positive regulation of gene expression
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0010997 anaphase-promoting complex binding
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0016311 dephosphorylation
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0016605 PML body
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021542 dentate gyrus development
GO:0021955 central nervous system neuron axonogenesis
GO:0030165 PDZ domain binding
GO:0030336 negative regulation of cell migration
GO:0030534 adult behavior
GO:0031175 neuron projection development
GO:0031642 negative regulation of myelination
GO:0031647 regulation of protein stability
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032286 central nervous system myelin maintenance
GO:0032355 response to estradiol
GO:0032535 regulation of cellular component size
GO:0032869 cellular response to insulin stimulus
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033198 response to ATP
GO:0033555 multicellular organismal response to stress
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0035749 myelin sheath adaxonal region
GO:0036294 cellular response to decreased oxygen levels
GO:0042493 response to drug
GO:0042711 maternal behavior
GO:0042802 identical protein binding
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043220 Schmidt-Lanterman incisure
GO:0043491 protein kinase B signaling
GO:0043542 endothelial cell migration
GO:0044320 cellular response to leptin stimulus
GO:0045211 postsynaptic membrane
GO:0045475 locomotor rhythm
GO:0045666 positive regulation of neuron differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045792 negative regulation of cell size
GO:0046621 negative regulation of organ growth
GO:0046685 response to arsenic-containing substance
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048679 regulation of axon regeneration
GO:0048681 negative regulation of axon regeneration
GO:0048738 cardiac muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0048870 cell motility
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050765 negative regulation of phagocytosis
GO:0050771 negative regulation of axonogenesis
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051548 negative regulation of keratinocyte migration
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051726 regulation of cell cycle
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051895 negative regulation of focal adhesion assembly
GO:0051896 regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060024 rhythmic synaptic transmission
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060074 synapse maturation
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0060341 regulation of cellular localization
GO:0060736 prostate gland growth
GO:0060997 dendritic spine morphogenesis
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071257 cellular response to electrical stimulus
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:0090071 negative regulation of ribosome biogenesis
GO:0090344 negative regulation of cell aging
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097105 presynaptic membrane assembly
GO:0097107 postsynaptic density assembly
GO:0099524 postsynaptic cytosol
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903690 negative regulation of wound healing, spreading of epidermal cells
GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990381 ubiquitin-specific protease binding
GO:1990782 protein tyrosine kinase binding
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000272 negative regulation of signaling receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000808 negative regulation of synaptic vesicle clustering
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR014020 Tensin phosphatase, C2 domainDomainDomain
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTENFamilyFamily
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR029023 Tensin-type phosphatase domainDomainDomain

Diseases

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