Entity Details

Primary name BAK_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08734
EntryNameBAK_MOUSE
FullNameBcl-2 homologous antagonist/killer
TaxID10090
Evidenceevidence at protein level
Length209
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBak1

GO terms

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GOName
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001836 release of cytochrome c from mitochondria
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420 brain development
GO:0007568 aging
GO:0008053 mitochondrial fusion
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 response to fungus
GO:0010046 response to mycotoxin
GO:0010225 response to UV-C
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0016020 membrane
GO:0016032 viral process
GO:0031018 endocrine pancreas development
GO:0031072 heat shock protein binding
GO:0031100 animal organ regeneration
GO:0031307 integral component of mitochondrial outer membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031966 mitochondrial membrane
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034644 cellular response to UV
GO:0035108 limb morphogenesis
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0044325 transmembrane transporter binding
GO:0044346 fibroblast apoptotic process
GO:0044877 protein-containing complex binding
GO:0045471 response to ethanol
GO:0045862 positive regulation of proteolysis
GO:0046872 metal ion binding
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048872 homeostasis of number of cells
GO:0051087 chaperone binding
GO:0051400 BH domain binding
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097145 BAK complex
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1902262 apoptotic process involved in blood vessel morphogenesis

Subcellular Location

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Subcellular Location
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR026308 Apoptosis regulator BAKFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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