Entity Details

Primary name CASPC_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08736
EntryNameCASPC_MOUSE
FullNameCaspase-12
TaxID10090
Evidenceevidence at protein level
Length419
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesCasp12

GO terms

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GOName
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0008234 cysteine-type peptidase activity
GO:0010663 positive regulation of striated muscle cell apoptotic process
GO:0016540 protein autoprocessing
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050727 regulation of inflammatory response
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0072557 IPAF inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097264 self proteolysis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site
IPR035713 Caspase-12FamilyFamily

Diseases

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