Entity Details

Primary name PHF8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ80TJ7
EntryNamePHF8_MOUSE
FullNameHistone lysine demethylase PHF8
TaxID10090
Evidenceevidence at protein level
Length1023
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesPhf8

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0005506 iron ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006482 protein demethylation
GO:0007420 brain development
GO:0008270 zinc ion binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0031965 nuclear membrane
GO:0032452 histone demethylase activity
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0033169 histone H3-K9 demethylation
GO:0035064 methylated histone binding
GO:0035574 histone H4-K20 demethylation
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0051864 histone demethylase activity (H3-K36 specific)
GO:0061188 negative regulation of ribosomal DNA heterochromatin assembly
GO:0070544 histone H3-K36 demethylation
GO:0071557 histone H3-K27 demethylation
GO:0071558 histone demethylase activity (H3-K27 specific)

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003347 JmjC domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR041070 Jumonji, helical domainDomainDomain

Diseases

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Interactions

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