Entity Details

Primary name CYLD_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ80TQ2
EntryNameCYLD_MOUSE
FullNameUbiquitin carboxyl-terminal hydrolase CYLD
TaxID10090
Evidenceevidence at protein level
Length952
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesCyld

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007346 regulation of mitotic cell cycle
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0036064 ciliary basal body
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043393 regulation of protein binding
GO:0045087 innate immune response
GO:0045577 regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0048872 homeostasis of number of cells
GO:0050727 regulation of inflammatory response
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0060544 regulation of necroptotic process
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070064 proline-rich region binding
GO:0070266 necroptotic process
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070536 protein K63-linked deubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097542 ciliary tip
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1902017 regulation of cilium assembly
GO:1903753 negative regulation of p38MAPK cascade
GO:1903829 positive regulation of cellular protein localization
GO:1990108 protein linear deubiquitination
GO:1990380 Lys48-specific deubiquitinase activity
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000938 CAP Gly-rich domainDomainDomain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR036859 CAP Gly-rich domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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