Entity Details

Primary name MFN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ80U63
EntryNameMFN2_MOUSE
FullNameMitofusin-2
TaxID10090
Evidenceevidence at protein level
Length757
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesMfn2

GO terms

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GOName
GO:0001825 blastocyst formation
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006626 protein targeting to mitochondrion
GO:0006915 apoptotic process
GO:0006986 response to unfolded protein
GO:0007006 mitochondrial membrane organization
GO:0008053 mitochondrial fusion
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
GO:0031267 small GTPase binding
GO:0031306 intrinsic component of mitochondrial outer membrane
GO:0031625 ubiquitin protein ligase binding
GO:0034497 protein localization to phagophore assembly site
GO:0042802 identical protein binding
GO:0043394 proteoglycan binding
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048593 camera-type eye morphogenesis
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051020 GTPase binding
GO:0051646 mitochondrion localization
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process

Subcellular Location

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Subcellular Location
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR006884 Fzo/mitofusin HR2 domainDomainDomain
IPR022812 DynaminFamilyFamily
IPR027089 Mitofusin-2FamilyFamily
IPR027094 Mitofusin familyFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030381 Dynamin-type guanine nucleotide-binding (G) domainDomainDomain

Diseases

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