Entity Details

Primary name CLOCK_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08785
EntryNameCLOCK_MOUSE
FullNameCircadian locomoter output cycles protein kaput
TaxID10090
Evidenceevidence at protein level
Length855
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesClock

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005694 chromosome
GO:0005726 perichromatin fibrils
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0031490 chromatin DNA binding
GO:0032922 circadian regulation of gene expression
GO:0033391 chromatoid body
GO:0042634 regulation of hair cycle
GO:0042752 regulation of circadian rhythm
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050729 positive regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0070888 E-box binding
GO:0071479 cellular response to ionizing radiation
GO:1990513 CLOCK-BMAL transcription complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
CLOCK_MOUSEKPCA_MOUSEMINT17347670 details
CLOCK_MOUSEKPCG_MOUSEMINT17347670 details
CLOCK_MOUSEBMAL1_MOUSEBioGRID, DIP, IntAct, MINT, UniProt14701732 16606840 16717091 16777965 17347670 18075593 18662546 18662547 20211142 20832105 20840750 21113167 22441692 22653727 23555304 23735699 24737000 25961797 26323038 26562092 28388406 30683868 9704006 details
CLOCK_MOUSEPER2_MOUSEBioGRID, IntAct14701732 16717091 18430226 18662546 20832105 21113167 21680841 22274616 23555304 32325033 details
CLOCK_MOUSECRY1_MOUSEBioGRID, DIP, IntAct14701732 16717091 16777965 18075593 18430226 18662546 23555304 25127877 25961797 details
CLOCK_MOUSESIR1_MOUSEBioGRID, IntAct18662546 18662547 details
CLOCK_MOUSEARNT_HUMANBioGRID, IntAct9704006 details
CLOCK_MOUSEPARP1_HUMANIntAct20832105 details
CLOCK_MOUSEPP1G_HUMANIntAct23555304 details
CLOCK_MOUSEKC1E_MOUSEIntAct23555304 details
CLOCK_MOUSERORB_HUMANIntAct23555304 details
CLOCK_MOUSEPP1A_HUMANIntAct23555304 details
CLOCK_MOUSENR1D2_HUMANIntAct23555304 details
CLOCK_MOUSE2AAB_HUMANIntAct23555304 details
CLOCK_MOUSERORG_HUMANIntAct23555304 details
CLOCK_MOUSE2A5D_HUMANIntAct23555304 details
CLOCK_MOUSEPP1B_HUMANIntAct23555304 details
CLOCK_MOUSECSK2B_HUMANIntAct23555304 details
CLOCK_MOUSECIPC_MOUSEIntAct23555304 details
CLOCK_MOUSENPAS2_HUMANIntAct23555304 details
CLOCK_MOUSEBHE41_MOUSEIntAct23555304 details
CLOCK_MOUSEBHE40_HUMANIntAct23555304 details
CLOCK_MOUSECRY2_MOUSEBioGRID, IntAct14701732 16717091 23555304 details
CLOCK_MOUSE2A5E_HUMANIntAct23555304 details
CLOCK_MOUSEDBP_HUMANIntAct23555304 details
CLOCK_MOUSEBMAL2_MOUSEDIP25961797 details
CLOCK_MOUSEH4_MOUSEBioGRID16678094 details
CLOCK_MOUSEKMT2A_HUMANDIP21113167 details
CLOCK_MOUSEDDB1_MOUSEDIP26323038 details
CLOCK_MOUSEPER1_MOUSEBioGRID14701732 16717091 21680841 32325033 details
CLOCK_MOUSEPER3_MOUSEBioGRID14701732 32325033 details
CLOCK_MOUSEEZH2_MOUSEBioGRID16717091 details
CLOCK_MOUSEKAT2B_MOUSEBioGRID16678094 details
CLOCK_MOUSEKAT5_MOUSEBioGRID16678094 details
CLOCK_MOUSERAE1L_MOUSEBioGRID30683868 details
CLOCK_MOUSENUP98_MOUSEBioGRID30683868 details