Entity Details

Primary name ERCC2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO08811
EntryNameERCC2_MOUSE
FullNameGeneral transcription and DNA repair factor IIH helicase subunit XPD
TaxID10090
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesErcc2

GO terms

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GOName
GO:0000439 transcription factor TFIIH core complex
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006366 transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007059 chromosome segregation
GO:0007568 aging
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0009411 response to UV
GO:0009650 UV protection
GO:0009791 post-embryonic development
GO:0021510 spinal cord development
GO:0022405 hair cycle process
GO:0030198 extracellular matrix organization
GO:0030282 bone mineralization
GO:0030674 protein-macromolecule adaptor activity
GO:0032289 central nervous system myelin formation
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035264 multicellular organism growth
GO:0035315 hair cell differentiation
GO:0040016 embryonic cleavage
GO:0042274 ribosomal small subunit biogenesis
GO:0043139 5'-3' DNA helicase activity
GO:0043249 erythrocyte maturation
GO:0043388 positive regulation of DNA binding
GO:0043588 skin development
GO:0045951 positive regulation of mitotic recombination
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0048568 embryonic organ development
GO:0048820 hair follicle maturation
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0060218 hematopoietic stem cell differentiation
GO:0070516 CAK-ERCC2 complex
GO:0071817 MMXD complex
GO:1901990 regulation of mitotic cell cycle phase transition

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001945 RAD3/XPD familyFamilyFamily
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR006554 Helicase-like, DEXD box c2 typeDomainDomain
IPR006555 ATP-dependent helicase, C-terminalDomainDomain
IPR010614 DEAD2DomainDomain
IPR010643 Helical and beta-bridge domainDomainDomain
IPR013020 ATP-dependent helicase Rad3/Chl1-likeFamilyFamily
IPR014013 Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-typeDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ERCC2_MOUSEUBC_MOUSEBioGRID28190767 details