Entity Details

Primary name NOD1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8BHB0
EntryNameNOD1_MOUSE
FullNameNucleotide-binding oligomerization domain-containing protein 1
TaxID10090
Evidenceevidence at protein level
Length953
SequenceStatuscomplete
DateCreated2003-03-28
DateModified2021-06-02

Ontological Relatives

GenesNod1

GO terms

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GOName
GO:0002221 pattern recognition receptor signaling pathway
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010942 positive regulation of cell death
GO:0016045 detection of bacterium
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035556 intracellular signal transduction
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045335 phagocytic vesicle
GO:0046330 positive regulation of JNK cascade
GO:0046658 anchored component of plasma membrane
GO:0050700 CARD domain binding
GO:0050830 defense response to Gram-positive bacterium
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071225 cellular response to muramyl dipeptide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Interactions

4 interactions