Entity Details

Primary name WRN_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO09053
EntryNameWRN_MOUSE
FullNameWerner syndrome ATP-dependent helicase homolog
TaxID10090
Evidenceevidence at protein level
Length1401
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesWrn

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000731 DNA synthesis involved in DNA repair
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007569 cell aging
GO:0008408 3'-5' exonuclease activity
GO:0009267 cellular response to starvation
GO:0009378 four-way junction helicase activity
GO:0010225 response to UV-C
GO:0010259 multicellular organism aging
GO:0016607 nuclear speck
GO:0016887 ATP hydrolysis activity
GO:0030145 manganese ion binding
GO:0031297 replication fork processing
GO:0032405 MutLalpha complex binding
GO:0032508 DNA duplex unwinding
GO:0040009 regulation of growth rate
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0044877 protein-containing complex binding
GO:0051345 positive regulation of hydrolase activity
GO:0051880 G-quadruplex DNA binding
GO:0061749 forked DNA-dependent helicase activity
GO:0061820 telomeric D-loop disassembly
GO:0061821 telomeric D-loop binding
GO:0070337 3'-flap-structured DNA binding
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0098530 positive regulation of strand invasion
GO:1902570 protein localization to nucleolus
GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR002121 HRDC domainDomainDomain
IPR002562 3'-5' exonuclease domainDomainDomain
IPR004589 DNA helicase, ATP-dependent, RecQ typeFamilyFamily
IPR010997 HRDC-like superfamilyFamilyHomologous superfamily
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR018982 RQC domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029491 Helicase Helix-turn-helix domainDomainDomain
IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink