Entity Details

Primary name TCAM2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8BJQ4
EntryNameTCAM2_MOUSE
FullNameTIR domain-containing adapter molecule 2
TaxID10090
Evidenceevidence at protein level
Length232
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesTicam2

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0001891 phagocytic cup
GO:0005149 interleukin-1 receptor binding
GO:0005543 phospholipid binding
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0042995 cell projection
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045323 interleukin-1 receptor complex
GO:0046982 protein heterodimerization activity
GO:0051607 defense response to virus
GO:0070671 response to interleukin-12
GO:0071222 cellular response to lipopolysaccharide
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:2000494 positive regulation of interleukin-18-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Early endosome
Endoplasmic reticulum
Golgi apparatus
Late endosome

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR015720 Transmembrane emp24 domain-containing proteinFamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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