Entity Details

Primary name M3K5_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO35099
EntryNameM3K5_MOUSE
FullNameMitogen-activated protein kinase kinase kinase 5
TaxID10090
Evidenceevidence at protein level
Length1380
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesMap3k5

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000287 magnesium ion binding
GO:0001934 positive regulation of protein phosphorylation
GO:0002931 response to ischemia
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009897 external side of plasma membrane
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010941 regulation of cell death
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034976 response to endoplasmic reticulum stress
GO:0038066 p38MAPK cascade
GO:0042060 wound healing
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045663 positive regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0051403 stress-activated MAPK cascade
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:0072577 endothelial cell apoptotic process
GO:0097300 programmed necrotic cell death
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900745 positive regulation of p38MAPK cascade
GO:1901216 positive regulation of neuron death
GO:1902170 cellular response to reactive nitrogen species
GO:1902911 protein kinase complex
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990604 IRE1-TRAF2-ASK1 complex

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR025136 MAP3K, TRAFs-binding domainDomainDomain
IPR043969 MAP3K, PH domainDomainDomain

Diseases

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