Entity Details

Primary name FLNA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8BTM8
EntryNameFLNA_MOUSE
FullNameFilamin-A
TaxID10090
Evidenceevidence at protein level
Length2647
SequenceStatuscomplete
DateCreated2003-11-07
DateModified2021-06-02

Ontological Relatives

GenesFlna

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001664 G protein-coupled receptor binding
GO:0001837 epithelial to mesenchymal transition
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005911 cell-cell junction
GO:0005938 cell cortex
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0008134 transcription factor binding
GO:0010977 negative regulation of neuron projection development
GO:0015459 potassium channel regulator activity
GO:0015629 actin cytoskeleton
GO:0016479 negative regulation of transcription by RNA polymerase I
GO:0019900 kinase binding
GO:0021943 formation of radial glial scaffolds
GO:0021987 cerebral cortex development
GO:0030018 Z disc
GO:0030036 actin cytoskeleton organization
GO:0030334 regulation of cell migration
GO:0030426 growth cone
GO:0030863 cortical cytoskeleton
GO:0031267 small GTPase binding
GO:0031523 Myb complex
GO:0031532 actin cytoskeleton reorganization
GO:0031852 mu-type opioid receptor binding
GO:0032231 regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032432 actin filament bundle
GO:0034394 protein localization to cell surface
GO:0034988 Fc-gamma receptor I complex binding
GO:0042177 negative regulation of protein catabolic process
GO:0042307 positive regulation of protein import into nucleus
GO:0042789 mRNA transcription by RNA polymerase II
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043113 receptor clustering
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0044295 axonal growth cone
GO:0044319 wound healing, spreading of cells
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045022 early endosome to late endosome transport
GO:0045184 establishment of protein localization
GO:0045216 cell-cell junction organization
GO:0046332 SMAD binding
GO:0048471 perinuclear region of cytoplasm
GO:0048680 positive regulation of axon regeneration
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0051015 actin filament binding
GO:0051020 GTPase binding
GO:0051220 cytoplasmic sequestering of protein
GO:0051764 actin crosslink formation
GO:0060271 cilium assembly
GO:0071526 semaphorin-plexin signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090042 tubulin deacetylation
GO:0090307 mitotic spindle assembly
GO:0097368 establishment of Sertoli cell barrier
GO:0097440 apical dendrite
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1902396 protein localization to bicellular tight junction
GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential
GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Perikaryon

Domains

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DomainNameCategoryType
IPR001298 Filamin/ABP280 repeatRepeatRepeat
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017868 Filamin/ABP280 repeat-likeRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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