Entity Details

Primary name MYL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12829
EntryNameMYL4_HUMAN
FullNameMyosin light chain 4
TaxID9606
Evidenceevidence at protein level
Length197
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesMYL4

GO terms

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GOName
GO:0002026 regulation of the force of heart contraction
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0016459 myosin complex
GO:0030049 muscle filament sliding
GO:0031672 A band
GO:0032038 myosin II heavy chain binding
GO:0032781 positive regulation of ATPase activity
GO:0051015 actin filament binding
GO:0060048 cardiac muscle contraction

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617280 OMIMAtrial fibrillation, familial, 18 (ATFB18)A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MYL4_HUMANPYRD2_HUMANBioGRID, IntAct21988832 details