Entity Details

Primary name CRBN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96SW2
EntryNameCRBN_HUMAN
FullNameProtein cereblon
TaxID9606
Evidenceevidence at protein level
Length442
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesCRBN

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR003111 Lon, substrate-binding domainDomainDomain
IPR004910 Yippee/Mis18/CereblonDomainDomain
IPR015947 PUA-like superfamilyFamilyHomologous superfamily
IPR034750 CULT domainDomainDomain

Diseases

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Disease IDSourceNameDescription
607417 OMIMMental retardation, autosomal recessive 2A (MRT2A)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00480 LenalidomideDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB08910 PomalidomideDrugbanksmall molecule

Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
CRBN_HUMANCUL4B_HUMANBioGRID, IntAct21145461 24292625 27142104 27294876 28514442 31973889 details
CRBN_HUMANSUV91_HUMANBioGRID, MINT23455924 details
CRBN_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
CRBN_HUMANGRB2_HUMANBioGRID, IntAct25814554 details
CRBN_HUMANP55G_HUMANBioGRID, IntAct25814554 details
CRBN_HUMANDP13B_HUMANBioGRID, IntAct25814554 details
CRBN_HUMANPAK5_HUMANBioGRID, IntAct25416956 31515488 details
CRBN_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
CRBN_HUMANIKZF1_HUMANBioGRID, DIP, MINT24292623 24292625 24328678 26183205 26990986 27329811 27338790 30385546 30458989 30760870 details
CRBN_HUMANMISP_HUMANBioGRID, IntAct32296183 details
CRBN_HUMANIKZF3_HUMANBioGRID, DIP24292623 24292625 24328678 26990986 27294876 30042095 details
CRBN_HUMANDDB1_HUMANBioGRID, DIP16964240 20223979 23983124 24292623 24292625 25108355 25860244 26131937 26231201 26909574 26990986 27142104 27294876 27338790 28425720 29370161 29892083 30190590 32132601 32235678 details
CRBN_HUMANKC1A_HUMANBioGRID, DIP26131937 26909574 26990986 details
CRBN_HUMANRBX1_HUMANBioGRID, DIP20223979 23983124 24292625 26990986 27029275 30042095 details
CRBN_HUMANKLF11_HUMANIntAct32814053 details
CRBN_HUMANCOQA1_HUMANIntAct32814053 details
CRBN_HUMANAAPK1_HUMANBioGRID21232561 details
CRBN_HUMANPSB4_HUMANBioGRID23026050 details
CRBN_HUMANMEIS2_HUMANBioGRID25043012 30458989 details
CRBN_HUMANGLNA_HUMANBioGRID26990986 28320958 details
CRBN_HUMANBASI_HUMANBioGRID27294876 details
CRBN_HUMANMOT1_HUMANBioGRID27294876 details
CRBN_HUMANERF3A_HUMANBioGRID27338790 details
CRBN_HUMANZFP91_HUMANBioGRID28530236 30190590 30385546 details
CRBN_HUMANUB2D1_HUMANBioGRID26909574 details
CRBN_HUMANBCL6_HUMANBioGRID30385546 details
CRBN_HUMANBCL6B_HUMANBioGRID30385546 details
CRBN_HUMANEGR1_HUMANBioGRID30385546 details
CRBN_HUMANEGR4_HUMANBioGRID30385546 details
CRBN_HUMANGZF1_HUMANBioGRID30385546 details
CRBN_HUMANHIC1_HUMANBioGRID30385546 details
CRBN_HUMANHIC2_HUMANBioGRID30385546 details
CRBN_HUMANSALL1_HUMANBioGRID30385546 details
CRBN_HUMANSALL3_HUMANBioGRID30385546 details
CRBN_HUMANSALL4_HUMANBioGRID30190590 30385546 32251415 32929090 details
CRBN_HUMANOSR1_HUMANBioGRID30385546 details
CRBN_HUMANOSR2_HUMANBioGRID30385546 details
CRBN_HUMANWIZ_HUMANBioGRID30385546 details
CRBN_HUMANZBT7A_HUMANBioGRID30385546 details
CRBN_HUMANZBT7B_HUMANBioGRID30385546 details
CRBN_HUMANSQSTM_HUMANBioGRID29272390 details
CRBN_HUMANP53_HUMANBioGRID30683842 details
CRBN_HUMANBRAF_HUMANBioGRID32778845 details
CRBN_HUMANCP19A_HUMANBioGRID32219443 details
CRBN_HUMANIMB1_HUMANBioGRID32132601 details
CRBN_HUMANAAKG1_HUMANBioGRID32333926 details
CRBN_HUMANCSN6_HUMANBioGRID, DIP, IntAct19295130 19615732 21145461 24292625 27029275 details
CRBN_HUMANT2FB_HUMANIntAct20195357 details
CRBN_HUMANCUL4A_HUMANBioGRID, DIP, IntAct16964240 20223979 21145461 23983124 24292623 24292625 25860244 26231201 26990986 27029275 27142104 27294876 28514442 31973889 32132601 32235678 details
CRBN_HUMANCSN5_HUMANBioGRID, DIP, IntAct21145461 24292625 27029275 31950832 details
CRBN_HUMANCSN8_HUMANBioGRID, DIP, IntAct24292625 27029275 28514442 details
CRBN_HUMANCSN1_HUMANBioGRID, DIP24292625 27029275 details
CRBN_HUMANCSN2_HUMANBioGRID, DIP24292625 27029275 details
CRBN_HUMANCSN3_HUMANBioGRID, DIP19295130 24292625 27029275 details
CRBN_HUMANCSN4_HUMANBioGRID, DIP19295130 24292625 27029275 details
CRBN_HUMANCSN7A_HUMANBioGRID, DIP24292625 27029275 details
CRBN_HUMANTNIK_HUMANIntAct31413325 details
CRBN_HUMANPSA2_HUMANBioGRID23026050 details
CRBN_HUMANCLCN1_HUMANBioGRID26021757 30458989 details
CRBN_HUMANM3K7_HUMANBioGRID27468689 details
CRBN_HUMANTRAF6_HUMANBioGRID27468689 details
CRBN_HUMANRABX5_HUMANBioGRID27601648 details
CRBN_HUMANDDA1_HUMANBioGRID24292625 details
CRBN_HUMANAPTX_HUMANBioGRID24292625 details
CRBN_HUMANDNLI4_HUMANBioGRID24292625 details
CRBN_HUMANCSN7B_HUMANBioGRID24292625 details
CRBN_HUMANSAMD1_HUMANBioGRID24292625 details
CRBN_HUMANDJB12_HUMANBioGRID24292625 details
CRBN_HUMANFA83G_HUMANBioGRID24292625 details
CRBN_HUMANSPRY4_HUMANBioGRID24292625 details
CRBN_HUMAN3BP1_HUMANBioGRID24292625 details
CRBN_HUMANDNLI3_HUMANBioGRID24292625 details
CRBN_HUMANXRCC1_HUMANBioGRID24292625 details
CRBN_HUMANDPOLB_HUMANBioGRID24292625 details
CRBN_HUMANBRCC3_HUMANBioGRID24292625 details
CRBN_HUMANJUN_HUMANBioGRID29748389 30458989 details
CRBN_HUMANZN692_HUMANBioGRID30385546 details
CRBN_HUMANFBX7_HUMANBioGRID29370161 30026574 details
CRBN_HUMANCUL1_HUMANBioGRID29370161 details
CRBN_HUMANSKP1_HUMANBioGRID29370161 details
CRBN_HUMANKCMA1_HUMANBioGRID29370161 details
CRBN_HUMANP63_HUMANBioGRID31591562 details
CRBN_HUMANRAF1_HUMANBioGRID32778845 details
CRBN_HUMANARAF_HUMANBioGRID32778845 details
CRBN_HUMANA4_HUMANBioGRID31983437 details
CRBN_HUMANCLCN2_HUMANBioGRID32466489 details
CRBN_HUMANPLK1_HUMANBioGRID32728610 details
CRBN_HUMANILF2_HUMANBioGRID33009960 details