Entity Details

Primary name ITAV_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06756
EntryNameITAV_HUMAN
FullNameIntegrin alpha-V
TaxID9606
Evidenceevidence at protein level
Length1048
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesITGAV

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001618 virus receptor activity
GO:0001846 opsonin binding
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005080 protein kinase C binding
GO:0005178 integrin binding
GO:0005245 voltage-gated calcium channel activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0031589 cell-substrate adhesion
GO:0032369 negative regulation of lipid transport
GO:0032587 ruffle membrane
GO:0033627 cell adhesion mediated by integrin
GO:0033690 positive regulation of osteoblast proliferation
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034683 integrin alphav-beta3 complex
GO:0034684 integrin alphav-beta5 complex
GO:0034685 integrin alphav-beta6 complex
GO:0034686 integrin alphav-beta8 complex
GO:0035579 specific granule membrane
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0035987 endodermal cell differentiation
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0043277 apoptotic cell clearance
GO:0043312 neutrophil degranulation
GO:0045335 phagocytic vesicle
GO:0045785 positive regulation of cell adhesion
GO:0046718 viral entry into host cell
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050431 transforming growth factor beta binding
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050764 regulation of phagocytosis
GO:0050840 extracellular matrix binding
GO:0050900 leukocyte migration
GO:0050919 negative chemotaxis
GO:0070062 extracellular exosome
GO:0070371 ERK1 and ERK2 cascade
GO:0070588 calcium ion transmembrane transport
GO:0071604 transforming growth factor beta production
GO:0085017 entry into host cell by a symbiont-containing vacuole
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901388 regulation of transforming growth factor beta activation
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:1990430 extracellular matrix protein binding
GO:2000536 negative regulation of entry of bacterium into host cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00451 LevothyroxineDrugbanksmall molecule

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
ITAV_HUMANITB3_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10891446 11546839 11884718 15299032 16099422 1694173 20639902 22178926 24658351 25792870 9686320 details
ITAV_HUMANANGL3_HUMANHPRD, IntAct11877390 details
ITAV_HUMANITB6_HUMANDIP, HPRD1532572 21677751 25383667 8120056 details
ITAV_HUMANITB1_HUMANBioGRID, DIP16424009 22178926 25792870 26344197 details
ITAV_HUMANSERPH_HUMANIntAct32814053 details
ITAV_HUMANKAPCA_HUMANIntAct32814053 details
ITAV_HUMANRD23A_HUMANIntAct32814053 details
ITAV_HUMANTGFR2_HUMANIntAct32814053 details
ITAV_HUMANLRRK1_HUMANIntAct32814053 details
ITAV_HUMANCCN3_HUMANBioGRID12902636 details
ITAV_HUMANAUP1_HUMANBioGRID12042322 details
ITAV_HUMANL1CAM_HUMANBioGRID, HPRD10871287 details
ITAV_HUMANCCN1_HUMANBioGRID, HPRD10821835 11287419 details
ITAV_HUMANPAXI_HUMANBioGRID16600665 30120307 details
ITAV_HUMANOSTP_HUMANBioGRID, HPRD10835423 7592829 details
ITAV_HUMANLG3BP_HUMANBioGRID24362527 details
ITAV_HUMANMK03_HUMANBioGRID23640055 details
ITAV_HUMANPA2GA_HUMANBioGRID18635536 details
ITAV_HUMANPAK4_HUMANBioGRID, HPRD12356872 23254288 details
ITAV_HUMANUBC_HUMANBioGRID28190767 details
ITAV_HUMANITB5_HUMANBioGRID, HPRD, IntAct12844492 1694173 7689573 details
ITAV_HUMANITB8_HUMANDIP, HPRD, IntAct1918072 30061598 details
ITAV_HUMANPTPRZ_HUMANBioGRID, I2D19141530 20639902 details
ITAV_HUMANFAK1_HUMANBioGRID, IntAct12844492 19889638 23397142 details
ITAV_HUMANSPEB_HUMANBioGRID, IntAct27173435 unassigned1312 details
ITAV_HUMANEDIL3_HUMANBioGRID, HPRD, IntAct11959660 28514442 details
ITAV_HUMANTGFB1_HUMANDIP, HPRD11970960 21677751 details
ITAV_HUMANADA17_HUMANUniProt30455686 details
ITAV_HUMANILK_HUMANBioGRID8538749 details
ITAV_HUMANMYPR_HUMANBioGRID, HPRD12196561 details
ITAV_HUMANMMP2_HUMANBioGRID, HPRD11134507 22349830 23254288 details
ITAV_HUMANCSF1R_HUMANBioGRID16600665 details
ITAV_HUMANCBL_HUMANBioGRID16600665 details
ITAV_HUMANBCAR1_HUMANBioGRID16600665 details
ITAV_HUMANKPB2_HUMANBioGRID16600665 details
ITAV_HUMANTSP1_HUMANBioGRID14963009 details
ITAV_HUMANEPHA2_HUMANBioGRID23874206 details
ITAV_HUMANNCOR1_HUMANBioGRID23640055 details
ITAV_HUMANNCOR2_HUMANBioGRID23640055 details
ITAV_HUMANEP300_HUMANBioGRID23640055 details
ITAV_HUMANMK01_HUMANBioGRID23640055 details
ITAV_HUMANSTAT1_HUMANBioGRID23640055 details
ITAV_HUMANSHC1_HUMANBioGRID19889638 details
ITAV_HUMANADAM9_HUMANBioGRID, HPRD15361064 16373656 details
ITAV_HUMANERBB2_HUMANBioGRID26222911 details
ITAV_HUMANANGP2_HUMANBioGRID16424009 details
ITAV_HUMANNUCL_HUMANBioGRID23161541 details
ITAV_HUMANITA4_HUMANBioGRID25792870 details
ITAV_HUMANITAV_HUMANBioGRID25792870 details
ITAV_HUMANPTN_HUMANBioGRID19141530 details
ITAV_HUMANMET_HUMANBioGRID28973887 details
ITAV_HUMANSDF1_HUMANBioGRID23381805 details
ITAV_HUMANST7_HUMANBioGRID29395067 details
ITAV_HUMANPGFRA_HUMANHPRD11953315 details
ITAV_HUMANPAR1_HUMANHPRD11278329 details
ITAV_HUMANZA2G_HUMANHPRD9813179 details
ITAV_HUMANP2RY2_HUMANHPRD11331301 details
ITAV_HUMANCD47_HUMANHPRD10545994 details
ITAV_HUMANCALR_HUMANHPRD12196561 details
ITAV_HUMANICAM4_HUMANHPRD11435317 details
ITAV_HUMANMMP14_HUMANHPRD11741954 details
ITAV_HUMANTHY1_HUMANHPRD15897908 details
ITAV_HUMANNID1_HUMANHPRD9686320 details