Entity Details

Primary name TRY2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07478
EntryNameTRY2_HUMAN
FullNameTrypsin-2
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesPRSS2

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0007586 digestion
GO:0019730 antimicrobial humoral response
GO:0022617 extracellular matrix disassembly
GO:0030307 positive regulation of cell growth
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0035578 azurophil granule lumen
GO:0043312 neutrophil degranulation
GO:0045785 positive regulation of cell adhesion

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01805 MonoisopropylphosphorylserineDrugbanksmall molecule
DB01973 O-Benzylsulfonyl-SerineDrugbanksmall molecule
DB02464 BenzylamineDrugbanksmall molecule
DB03127 BenzamidineDrugbanksmall molecule
DB03976 PhosphorylisopropaneDrugbanksmall molecule
DB04325 PhenethylamineDrugbanksmall molecule
DB04410 3-PhenylpropylamineDrugbanksmall molecule