Entity Details

Primary name CCL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13500
EntryNameCCL2_HUMAN
FullNameC-C motif chemokine 2
TaxID9606
Evidenceevidence at protein level
Length99
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesCCL2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0002548 monocyte chemotaxis
GO:0004672 protein kinase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008009 chemokine activity
GO:0008360 regulation of cell shape
GO:0009617 response to bacterium
GO:0009887 animal organ morphogenesis
GO:0019079 viral genome replication
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019725 cellular homeostasis
GO:0030593 neutrophil chemotaxis
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031727 CCR2 chemokine receptor binding
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035684 helper T cell extravasation
GO:0036499 PERK-mediated unfolded protein response
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0043615 astrocyte cell migration
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0048020 CCR chemokine receptor binding
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050870 positive regulation of T cell activation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0090280 positive regulation of calcium ion import
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000427 positive regulation of apoptotic cell clearance
GO:2000502 negative regulation of natural killer cell chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000827 CC chemokine, conserved siteSiteConserved site
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01055 MimosineDrugbanksmall molecule
DB01406 DanazolDrugbanksmall molecule
DB09301 Chondroitin sulfateDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
CCL2_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
CCL2_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
CCL2_HUMANCCL5_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANPLF4_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCCL15_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCCL8_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCCL11_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANIL8_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCXCL9_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCXL17_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCXL13_HUMANbhf-ucl28381538 details
CCL2_HUMANCCL26_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANCC4L_HUMANbhf-ucl, BioGRID28381538 details
CCL2_HUMANPROM1_HUMANIntAct23084749 details
CCL2_HUMANACKR1_HUMANBioGRID, HPRD13679391 17416748 details
CCL2_HUMANCCL2_HUMANBioGRID, HPRD7651403 8639605 8989326 details
CCL2_HUMANCCR3_HUMANBioGRID8642344 details
CCL2_HUMANCSPG2_HUMANBioGRID, HPRD11083865 details
CCL2_HUMANMOT8_HUMANBioGRID32296183 details
CCL2_HUMANS22A1_HUMANBioGRID31318583 details
CCL2_HUMANS22A2_HUMANBioGRID31318583 details
CCL2_HUMANCCL13_HUMANBioGRID28381538 details
CCL2_HUMANXCL2_HUMANBioGRID28381538 details
CCL2_HUMANCCL4_HUMANBioGRID28381538 details
CCL2_HUMANCDC6_HUMANBioGRID21383955 details
CCL2_HUMANORC2_HUMANBioGRID21383955 details
CCL2_HUMANORC4_HUMANBioGRID21383955 details
CCL2_HUMANMCM2_HUMANBioGRID21383955 details
CCL2_HUMANMCM3_HUMANBioGRID21383955 details
CCL2_HUMANMCM7_HUMANBioGRID21383955 details
CCL2_HUMANCDC45_HUMANBioGRID21383955 details
CCL2_HUMANPCNA_HUMANBioGRID21383955 details
CCL2_HUMANMMP1_HUMANHPRD12149192 9558113 details
CCL2_HUMANMMP8_HUMANHPRD12149192 9558113 details
CCL2_HUMANMMP3_HUMANHPRD12149192 9558113 details
CCL2_HUMANCCR10_HUMANHPRD10706668 9364936 details
CCL2_HUMANCCR1_HUMANHPRD8631787 details
CCL2_HUMANCCR2_HUMANHPRD10529171 9287323 details
CCL2_HUMANCCR5_HUMANHPRD10477718 details
CCL2_HUMANACKR4_HUMANHPRD10734104 details
CCL2_HUMANACKR2_HUMANHPRD9364936 9405404 details