Entity Details

Primary name BIRC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13490
EntryNameBIRC2_HUMAN
FullNameBaculoviral IAP repeat-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length618
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBIRC2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001741 XY body
GO:0001890 placenta development
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007166 cell surface receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016579 protein deubiquitination
GO:0016740 transferase activity
GO:0031398 positive regulation of protein ubiquitination
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0039535 regulation of RIG-I signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0045595 regulation of cell differentiation
GO:0047485 protein N-terminus binding
GO:0050727 regulation of inflammatory response
GO:0051087 chaperone binding
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0061630 ubiquitin protein ligase activity
GO:0070266 necroptotic process
GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0098770 FBXO family protein binding
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000377 regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001370 BIR repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR041933 BIRC2/BIRC3, UBA domainDomainDomain

Diseases

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Interactions

121 interactions

InteractorPartnerSourcesPublicationsLink
BIRC2_HUMANDBLOH_HUMANBioGRID, HPRD, IntAct, MINT10929712 12218061 12525502 12865429 14960576 16282325 19153467 19506082 20957035 25065467 25246529 27476169 28514442 30359437 details
BIRC2_HUMANCASP7_HUMANBioGRID, HPRD, IntAct11084335 15580265 16339151 19258326 9384571 details
BIRC2_HUMANCASP9_HUMANBioGRID, HPRD, IntAct11084335 15069192 16339151 16701639 19153467 25241761 25416956 27197231 31515488 32296183 9545235 details
BIRC2_HUMANCASP3_HUMANBioGRID, HPRD, IntAct11084335 11106668 17069460 19258326 9384571 details
BIRC2_HUMANMAGAB_HUMANBioGRID, HPRD, IntAct16189514 details
BIRC2_HUMANPLAK_HUMANBioGRID, HPRD, IntAct16189514 details
BIRC2_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct, MINT10753917 11181075 11907583 15861135 16189514 16263936 16282325 16891304 18997794 19506082 19584093 19815541 20184394 20348096 20447407 20562859 21331077 21653699 21903422 21988832 23007157 23524849 24276241 25241761 25681446 25716317 25882049 27534557 28514442 30359437 30561431 32296183 8548810 8643514 8943045 9384571 details
BIRC2_HUMANUB2J1_HUMANBioGRID, HPRD, IntAct15861135 19690564 28321712 details
BIRC2_HUMANUBE2W_HUMANBioGRID, IntAct19690564 details
BIRC2_HUMANUBC_HUMANBioGRID, MINT18931663 19373254 21113135 25494483 27182664 details
BIRC2_HUMANTSG10_HUMANBioGRID, IntAct, MINT21516116 25416956 details
BIRC2_HUMANAB17A_HUMANBioGRID, MINT21516116 details
BIRC2_HUMANTUFT1_HUMANBioGRID, MINT21516116 details
BIRC2_HUMANTRAF1_HUMANBioGRID, HPRD, IntAct, MINT11907583 16891304 20447407 21903422 21988832 23524849 25996949 28514442 30561431 8548810 8943045 9384571 details
BIRC2_HUMANBIRC2_HUMANBioGRID, DIP, IntAct11907583 18022362 18570872 19810754 20447407 21048196 21113135 21331077 21393245 21549626 22021857 22493164 23166698 24975362 25065467 25383668 25527291 30181285 30561431 31515488 details
BIRC2_HUMANTRI34_HUMANBioGRID, IntAct22493164 details
BIRC2_HUMANRN181_HUMANBioGRID, IntAct22493164 details
BIRC2_HUMANCBLC_HUMANBioGRID, IntAct22493164 details
BIRC2_HUMANDZIP3_HUMANBioGRID, IntAct22493164 details
BIRC2_HUMANRIPK2_HUMANBioGRID, HPRD, IntAct19464198 21931591 30026309 9642260 9705938 details
BIRC2_HUMANRIPK1_HUMANBioGRID, IntAct18570872 19854138 21113135 21931591 23972990 26612615 27197231 29021293 29955050 30561431 details
BIRC2_HUMANRIPK3_HUMANBioGRID, IntAct21931591 details
BIRC2_HUMANUB2D1_HUMANBioGRID, IntAct12525502 19854138 21048196 21113135 21931591 22117219 24633224 24975362 25527291 27197231 28542143 details
BIRC2_HUMANHTRA2_HUMANBioGRID, HPRD, IntAct11583623 11604410 12865429 28514442 31617661 details
BIRC2_HUMANRAC1_HUMANBioGRID, MINT22117219 24276241 25301945 details
BIRC2_HUMANOTUB1_HUMANBioGRID, MINT23524849 details
BIRC2_HUMANNEMO_HUMANBioGRID, HPRD, IntAct, MINT12867425 20932475 22990857 23524849 23732909 30561431 details
BIRC2_HUMANNMB_HUMANBioGRID, IntAct25416956 25910212 32296183 details
BIRC2_HUMANGFAP_HUMANBioGRID, IntAct25416956 details
BIRC2_HUMANBIRC7_HUMANBioGRID, IntAct21113135 22711539 25416956 26186194 28514442 31515488 details
BIRC2_HUMANPPM1K_HUMANBioGRID, IntAct21516116 25416956 32296183 details
BIRC2_HUMANEAF2_HUMANBioGRID, IntAct25416956 details
BIRC2_HUMANGCC1_HUMANBioGRID, IntAct25416956 32296183 details
BIRC2_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 28514442 31515488 details
BIRC2_HUMANEXOS5_HUMANBioGRID, IntAct25416956 32296183 details
BIRC2_HUMANBOLA1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
BIRC2_HUMANTCAF1_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANMTG8_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANKDM1A_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANBMX_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANRFC5_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANBLK_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANNXF1_HUMANBioGRID, IntAct32296183 details
BIRC2_HUMANUB2D3_HUMANBioGRID, DIP12525502 21113135 25383668 details
BIRC2_HUMANJPH3_HUMANIntAct32814053 details
BIRC2_HUMANERF3A_HUMANBioGRID12865429 details
BIRC2_HUMANRAF1_HUMANBioGRID19011619 details
BIRC2_HUMANENPL_HUMANBioGRID18239673 25361076 details
BIRC2_HUMANFBX7_HUMANBioGRID, HPRD16510124 22212761 27503909 details
BIRC2_HUMANBIRC5_HUMANBioGRID15218035 15665297 25635055 details
BIRC2_HUMANTS101_HUMANBioGRID21113135 details
BIRC2_HUMANUBE2B_HUMANBioGRID21113135 details
BIRC2_HUMANUB2D2_HUMANBioGRID11907583 19258326 21113135 21393245 30181285 30523153 details
BIRC2_HUMANUB2Q2_HUMANBioGRID21113135 details
BIRC2_HUMANUBE2S_HUMANBioGRID21048196 21113135 details
BIRC2_HUMANCASP2_HUMANBioGRID16701639 29875129 details
BIRC2_HUMANE2F1_HUMANBioGRID21653699 28542143 30359437 details
BIRC2_HUMANUB2V1_HUMANBioGRID18570872 details
BIRC2_HUMANMAD1_HUMANBioGRID18082613 details
BIRC2_HUMANPGAM5_HUMANBioGRID23201124 details
BIRC2_HUMANIKKE_HUMANBioGRID23453969 details
BIRC2_HUMANRHOA_HUMANBioGRID24276241 details
BIRC2_HUMANCDC42_HUMANBioGRID24276241 28661476 details
BIRC2_HUMANPACS2_HUMANBioGRID24633224 details
BIRC2_HUMANM3K2_HUMANBioGRID24975362 details
BIRC2_HUMANM3K3_HUMANBioGRID24975362 details
BIRC2_HUMANPCSK9_HUMANBioGRID23085658 details
BIRC2_HUMANXPO2_HUMANBioGRID26668314 details
BIRC2_HUMANGLMN_HUMANBioGRID29191979 details
BIRC2_HUMANUBE2N_HUMANBioGRID28244869 29642013 details
BIRC2_HUMANIF4E_HUMANBioGRID28852129 details
BIRC2_HUMANCHIP_HUMANBioGRID28852129 details
BIRC2_HUMANMD1L1_HUMANBioGRID30181285 details
BIRC2_HUMANPROF2_HUMANBioGRID30352681 details
BIRC2_HUMANBOLA2_HUMANBioGRID32296183 details
BIRC2_HUMANTNFA_HUMANBioGRID, IntAct, MINT12887920 20005846 21822306 23815148 25911380 27307491 30561431 details
BIRC2_HUMANCASP8_HUMANBioGRID, IntAct12887920 15069192 22274400 27810922 details
BIRC2_HUMANTNR1A_HUMANBioGRID, IntAct18022363 19815541 25681446 30420664 30561431 8943045 details
BIRC2_HUMANM3K14_HUMANBioGRID, IntAct18022362 20184394 25246529 details
BIRC2_HUMANUBXN1_HUMANBioGRID, IntAct18775313 25681446 details
BIRC2_HUMANTNR12_HUMANBioGRID, IntAct21525013 details
BIRC2_HUMANRIPK4_HUMANIntAct21931591 details
BIRC2_HUMANTRAF3_HUMANBioGRID, IntAct, MINT20097753 23524849 30561431 details
BIRC2_HUMANTNR3_HUMANBioGRID, HPRD, IntAct12571250 26186194 28514442 details
BIRC2_HUMANXIAP_HUMANBioGRID, IntAct16263936 17069460 22711539 28514442 details
BIRC2_HUMANTRADD_HUMANBioGRID, HPRD, IntAct30561431 8943045 details
BIRC2_HUMANTNAP3_HUMANBioGRID, IntAct24008839 30561431 32015333 details
BIRC2_HUMANTNF14_HUMANBioGRID12571250 details
BIRC2_HUMANBCL10_HUMANBioGRID10753917 16775419 details
BIRC2_HUMANADRM1_HUMANBioGRID18939944 details
BIRC2_HUMANXAF1_HUMANBioGRID17613533 details
BIRC2_HUMANUB2L3_HUMANBioGRID12525502 details
BIRC2_HUMANTRAF6_HUMANBioGRID20097753 20932475 details
BIRC2_HUMANMAVS_HUMANBioGRID20097753 details
BIRC2_HUMANUBP19_HUMANBioGRID21849505 details
BIRC2_HUMANTRI32_HUMANBioGRID21628460 details
BIRC2_HUMANNOD2_HUMANBioGRID22607974 details
BIRC2_HUMANSH3K1_HUMANBioGRID15707590 details
BIRC2_HUMANAIMP2_HUMANBioGRID19584093 details
BIRC2_HUMANBIRC3_HUMANBioGRID17069460 details
BIRC2_HUMANTNR5_HUMANBioGRID, HPRD11562359 20614026 21041727 details
BIRC2_HUMANDHX9_HUMANBioGRID19893574 details
BIRC2_HUMANILF3_HUMANBioGRID19893574 details
BIRC2_HUMANILF2_HUMANBioGRID19893574 details
BIRC2_HUMANIF2B1_HUMANBioGRID19893574 24704827 details
BIRC2_HUMANGSK3B_HUMANBioGRID19698783 details
BIRC2_HUMANCD40L_HUMANBioGRID23918987 details
BIRC2_HUMANEGFR_HUMANBioGRID23972990 details
BIRC2_HUMANNUCG_HUMANBioGRID25139236 details
BIRC2_HUMANCASPA_HUMANBioGRID15069192 details
BIRC2_HUMANUB2L6_HUMANBioGRID12525502 details
BIRC2_HUMANEGLN3_HUMANBioGRID26612615 details
BIRC2_HUMANTLR3_HUMANBioGRID27810922 details
BIRC2_HUMANULK1_HUMANBioGRID27693792 details
BIRC2_HUMANTOM20_HUMANBioGRID27693792 details
BIRC2_HUMANMRE11_HUMANBioGRID28363998 details
BIRC2_HUMANDMBT1_HUMANBioGRID27637083 details
BIRC2_HUMANSQSTM_HUMANBioGRID26416459 details
BIRC2_HUMANUBB_HUMANHPRD16510124 details
BIRC2_HUMANGAS1_HUMANHPRD11906213 details