Entity Details

Primary name SIR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IXJ6
EntryNameSIR2_HUMAN
FullNameNAD-dependent protein deacetylase sirtuin-2
TaxID9606
Evidenceevidence at protein level
Length389
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSIRT2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000781 chromosome, telomeric region
GO:0000792 heterochromatin
GO:0003682 chromatin binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0006342 chromatin silencing
GO:0006348 chromatin silencing at telomere
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0006914 autophagy
GO:0007084 mitotic nuclear membrane reassembly
GO:0007096 regulation of exit from mitosis
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016575 histone deacetylation
GO:0017136 NAD-dependent histone deacetylase activity
GO:0021762 substantia nigra development
GO:0022011 myelination in peripheral nervous system
GO:0030426 growth cone
GO:0030496 midbody
GO:0031641 regulation of myelination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033010 paranodal junction
GO:0033270 paranode region of axon
GO:0033558 protein deacetylase activity
GO:0034599 cellular response to oxidative stress
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035035 histone acetyltransferase binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042177 negative regulation of protein catabolic process
GO:0042325 regulation of phosphorylation
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0044224 juxtaparanode region of axon
GO:0044242 cellular lipid catabolic process
GO:0045087 innate immune response
GO:0045599 negative regulation of fat cell differentiation
GO:0045836 positive regulation of meiotic nuclear division
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051726 regulation of cell cycle
GO:0051775 response to redox state
GO:0051781 positive regulation of cell division
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 cellular response to caloric restriction
GO:0070403 NAD+ binding
GO:0070446 negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071219 cellular response to molecule of bacterial origin
GO:0071456 cellular response to hypoxia
GO:0071872 cellular response to epinephrine stimulus
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
GO:0090042 tubulin deacetylation
GO:0097386 glial cell projection
GO:1900119 positive regulation of execution phase of apoptosis
GO:1900195 positive regulation of oocyte maturation
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:1900425 negative regulation of defense response to bacterium
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Subcellular Location

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Subcellular Location
Cell projection
Chromosome
Cytoplasm
Midbody
Myelin membrane
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR017328 Sirtuin, class IFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15493 CambinolDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
SIR2_HUMANFZR1_HUMANBioGRID, IntAct22014574 details
SIR2_HUMANCDC20_HUMANBioGRID, IntAct22014574 details
SIR2_HUMANRAD51_HUMANBioGRID, MINT25640309 details
SIR2_HUMANTF65_HUMANIntAct21081649 details
SIR2_HUMANOXYR_HUMANBioGRID, MINT28298427 details
SIR2_HUMANH31_HUMANBioGRID19270680 19801601 details
SIR2_HUMANEP300_HUMANBioGRID18722353 18995842 23934153 details
SIR2_HUMANFOXO1_HUMANBioGRID15220471 20543840 24419059 details
SIR2_HUMANXPO1_HUMANBioGRID22833565 26673895 details
SIR2_HUMANTBA4A_HUMANBioGRID, HPRD12620231 details
SIR2_HUMANMDM2_HUMANBioGRID28196907 details
SIR2_HUMANPA24A_HUMANBioGRID26303530 details
SIR2_HUMANCDK2_HUMANBioGRID26303530 details
SIR2_HUMANGDIR1_HUMANBioGRID26719334 details
SIR2_HUMANHIF1A_HUMANBioGRID24681946 details
SIR2_HUMANSERA_HUMANBioGRID32783943 details
SIR2_HUMANHXA10_HUMANHPRD15213244 details
SIR2_HUMANKAT2B_HUMANBioGRID, HPRD, IntAct12887892 30482390 details
SIR2_HUMANKAT2A_HUMANHPRD, IntAct12887892 details
SIR2_HUMANHDAC6_HUMANBioGRID, HPRD, IntAct12620231 17516032 details
SIR2_HUMANSPOP_HUMANBioGRID, IntAct17353931 28073696 details
SIR2_HUMANCC14B_HUMANHPRD, MINT12697818 details
SIR2_HUMANMYC_HUMANIntAct23217706 details
SIR2_HUMANG6PD_HUMANMINT24769394 details
SIR2_HUMANBUB1B_HUMANMINT24825348 details
SIR2_HUMANH4_HUMANIntAct21081649 details
SIR2_HUMANSHAN3_HUMANMINT21653829 details
SIR2_HUMANDNJB6_HUMANBioGRID20159555 details
SIR2_HUMANDNJB8_HUMANBioGRID20159555 details
SIR2_HUMANCPSF5_HUMANBioGRID17172643 details
SIR2_HUMANPAPOA_HUMANBioGRID17172643 details
SIR2_HUMANING1_HUMANBioGRID14522900 details
SIR2_HUMANRET1_HUMANBioGRID18193082 details
SIR2_HUMANSIR1_HUMANBioGRID18193082 details
SIR2_HUMANPCKGC_HUMANBioGRID21726808 details
SIR2_HUMANRUNX3_HUMANBioGRID21511279 details
SIR2_HUMANCBLB_HUMANBioGRID25285640 details
SIR2_HUMANCBL_HUMANBioGRID25285640 details
SIR2_HUMANACLY_HUMANBioGRID23932781 details
SIR2_HUMANGCKR_HUMANBioGRID26620281 details
SIR2_HUMANSKP2_HUMANBioGRID26942878 details
SIR2_HUMANUNK_HUMANBioGRID29395067 details
SIR2_HUMANENTR1_HUMANBioGRID29395067 details
SIR2_HUMANTBK1_HUMANBioGRID29395067 details
SIR2_HUMANSYVN1_HUMANBioGRID31932479 details
SIR2_HUMANSP140_HUMANHPRD12887892 details