Entity Details

Primary name SOCS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14543
EntryNameSOCS3_HUMAN
FullNameSuppressor of cytokine signaling 3
TaxID9606
Evidenceevidence at protein level
Length225
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS3

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0004860 protein kinase inhibitor activity
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045597 positive regulation of cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0050728 negative regulation of inflammatory response
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
GO:0070102 interleukin-6-mediated signaling pathway
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028414 Suppressor of cytokine signalling 3FamilyFamily
IPR035863 SOCS3, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
SOCS3_HUMANPIN1_HUMANBioGRID, HPRD, IntAct16169070 details
SOCS3_HUMANMAP1S_HUMANBioGRID, MINT19027008 details
SOCS3_HUMANRBX2_HUMANBioGRID, IntAct15601820 24438103 details
SOCS3_HUMANCUL5_HUMANBioGRID, IntAct15601820 17135358 24438103 30166453 details
SOCS3_HUMANELOC_HUMANBioGRID, HPRD, IntAct10051596 12783885 15601820 17135358 22084247 30166453 details
SOCS3_HUMANI12R2_HUMANBioGRID, MINT14559241 details
SOCS3_HUMANJAK2_HUMANBioGRID, HPRD, MINT10421843 10882725 11314018 14517242 15514089 19543316 22342841 24354892 24438103 29752723 9344848 details
SOCS3_HUMANEPOR_HUMANBioGRID, HPRD, MINT10882725 12027890 details
SOCS3_HUMANRASA1_HUMANBioGRID, HPRD, MINT11331873 details
SOCS3_HUMANGFRA1_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANBIK_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANZEP1_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANNDKM_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANRL7A_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANTFR2_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANTES_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANRBMX_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANTXD11_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANRNF31_HUMANBioGRID, IntAct21988832 details
SOCS3_HUMANMK11_HUMANBioGRID, MINT21900206 details
SOCS3_HUMANMK06_HUMANBioGRID, MINT21900206 details
SOCS3_HUMANPDPK1_HUMANBioGRID, MINT21900206 details
SOCS3_HUMANANDR_HUMANBioGRID, IntAct24728074 details
SOCS3_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
SOCS3_HUMANKIT_HUMANBioGRID, IntAct24728074 details
SOCS3_HUMANMET_HUMANBioGRID, IntAct24728074 details
SOCS3_HUMANSH22A_HUMANBioGRID, IntAct25814554 details
SOCS3_HUMANTRDN_HUMANBioGRID, IntAct25814554 details
SOCS3_HUMAN1433T_HUMANBioGRID, IntAct25814554 details
SOCS3_HUMANEGFR_HUMANBioGRID, HPRD, IntAct12070153 24658140 25402006 31980649 details
SOCS3_HUMANYES_HUMANBioGRID, IntAct25416956 32296183 details
SOCS3_HUMANK1958_HUMANBioGRID, IntAct25416956 32296183 details
SOCS3_HUMANTXK_HUMANBioGRID, IntAct32296183 details
SOCS3_HUMANBLK_HUMANBioGRID, IntAct32296183 details
SOCS3_HUMANINSR_HUMANBioGRID, HPRD11071852 12560330 15514089 details
SOCS3_HUMANLEPR_HUMANBioGRID, HPRD11018044 21239736 details
SOCS3_HUMANIL6RB_HUMANBioGRID, HPRD10777583 10946280 12403768 24438103 32548823 details
SOCS3_HUMANPTN11_HUMANBioGRID, HPRD10777583 12403768 17138568 details
SOCS3_HUMANGHR_HUMANBioGRID, HPRD10585430 details
SOCS3_HUMANFAK2_HUMANBioGRID18507841 9344848 details
SOCS3_HUMANIGF1R_HUMANBioGRID, HPRD11071852 details
SOCS3_HUMANACADV_HUMANBioGRID22093833 details
SOCS3_HUMANFAK1_HUMANBioGRID14517242 16007195 18031698 25416956 details
SOCS3_HUMANCUED2_HUMANBioGRID22084247 details
SOCS3_HUMANJAK1_HUMANBioGRID, HPRD10373548 10707961 details
SOCS3_HUMANIL2RB_HUMANBioGRID, HPRD10373548 details
SOCS3_HUMANTFDP1_HUMANBioGRID18687693 details
SOCS3_HUMANA4_HUMANBioGRID21832049 details
SOCS3_HUMANABL1_HUMANBioGRID22787435 30236924 details
SOCS3_HUMANTBK1_HUMANBioGRID25939384 details
SOCS3_HUMANIRF7_HUMANBioGRID29712772 details
SOCS3_HUMANERBB2_HUMANBioGRID22973453 details
SOCS3_HUMANERBB3_HUMANBioGRID22973453 details
SOCS3_HUMANERBB4_HUMANBioGRID22973453 details
SOCS3_HUMANCAVN1_HUMANBioGRID32548823 details
SOCS3_HUMANELOB_HUMANBioGRID, HPRD, IntAct10051596 15601820 16007195 17135358 30166453 details
SOCS3_HUMANSNAI1_HUMANIntAct25203322 details
SOCS3_HUMANAMRA1_HUMANBioGRID, IntAct28514442 30166453 details
SOCS3_HUMANPRLR_HUMANBioGRID, HPRD11713228 details
SOCS3_HUMANCXCR4_HUMANBioGRID, HPRD12163560 details
SOCS3_HUMANCSF1R_HUMANBioGRID, HPRD12133942 details
SOCS3_HUMANNONO_HUMANBioGRID18952062 details
SOCS3_HUMANM3K7_HUMANBioGRID16543409 details
SOCS3_HUMANTRAF6_HUMANBioGRID16543409 26633718 details
SOCS3_HUMANM3K5_HUMANBioGRID16407264 details
SOCS3_HUMANVHL_HUMANBioGRID21685897 details
SOCS3_HUMANDAB1_HUMANBioGRID17974915 details
SOCS3_HUMANETV6_HUMANBioGRID11314018 details
SOCS3_HUMANJIP1_HUMANBioGRID18055217 details
SOCS3_HUMANSOCS2_HUMANBioGRID, HPRD16199887 details
SOCS3_HUMANSIGL7_HUMANBioGRID17138568 details
SOCS3_HUMANFGFR3_HUMANBioGRID16410555 details
SOCS3_HUMANNFKB1_HUMANBioGRID21451109 details
SOCS3_HUMANTF65_HUMANBioGRID21451109 30766526 details
SOCS3_HUMANREL_HUMANBioGRID21451109 details
SOCS3_HUMANIKBA_HUMANBioGRID21451109 details
SOCS3_HUMANTNF10_HUMANBioGRID21308719 details
SOCS3_HUMANJAK3_HUMANBioGRID, HPRD10373548 15385932 details
SOCS3_HUMANLCK_HUMANBioGRID21234523 details
SOCS3_HUMANIRS1_HUMANBioGRID, HPRD12228220 15514089 details
SOCS3_HUMANIRS2_HUMANBioGRID, HPRD15514089 details
SOCS3_HUMANPTK6_HUMANBioGRID22547065 details
SOCS3_HUMANSTAT3_HUMANBioGRID31748929 details
SOCS3_HUMANPP2BB_HUMANHPRD11970967 details
SOCS3_HUMANCSF3R_HUMANHPRD12133942 details
SOCS3_HUMANKC1E_HUMANHPRD15070676 details
SOCS3_HUMANBCL10_HUMANHPRD15213237 details