Entity Details

Primary name RORB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92753
EntryNameRORB_HUMAN
FullNameNuclear receptor ROR-beta
TaxID9606
Evidenceevidence at protein level
Length470
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007601 visual perception
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008502 melatonin receptor activity
GO:0035881 amacrine cell differentiation
GO:0042462 eye photoreceptor cell development
GO:0042752 regulation of circadian rhythm
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0048511 rhythmic process
GO:0060041 retina development in camera-type eye
GO:0071300 cellular response to retinoic acid
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003079 Nuclear receptor RORFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044101 Retinoid-related orphan receptors, DNA-binding domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618357 OMIMEpilepsy, idiopathic generalized 15 (EIG15)An autosomal dominant form of idiopathic generalized epilepsy, a disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. EIG15 is characterized by onset of variable types of seizures in the first decade of life. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01065 MelatoninDrugbanksmall molecule