Entity Details

Primary name SMAD5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99717
EntryNameSMAD5_HUMAN
FullNameMothers against decapentaplegic homolog 5
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSMAD5

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001657 ureteric bud development
GO:0001880 Mullerian duct regression
GO:0002051 osteoblast fate commitment
GO:0003161 cardiac conduction system development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0017151 DEAD/H-box RNA helicase binding
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030509 BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0051216 cartilage development
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0060395 SMAD protein signal transduction
GO:0070411 I-SMAD binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071407 cellular response to organic cyclic compound
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
SMAD5_HUMANSMUF2_HUMANBioGRID, HPRD, IntAct, MINT15221015 15231748 20484049 28514442 details
SMAD5_HUMANSMUF1_HUMANBioGRID, MINT11278251 12857866 15221015 15231748 16516194 17676934 18641638 19914168 20484049 22670624 details
SMAD5_HUMANCXXC5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANSOX7_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANPTN12_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANSF3B1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANMTMRA_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANPNKP_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANSFPQ_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANSNRPA_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANPSD11_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANU2AF2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANSOX5_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANHBG2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANRBM4_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANRYR2_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANCHMP3_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANBCAT1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANPPIL4_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANRU17_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANAN13A_HUMANBioGRID, MINT15231748 details
SMAD5_HUMANWWP1_HUMANBioGRID, HPRD, MINT15221015 15231748 details
SMAD5_HUMANNEDD4_HUMANBioGRID, MINT15231748 details
SMAD5_HUMANSMAD4_HUMANBioGRID, HPRD, MINT10531362 15231748 16516194 details
SMAD5_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
SMAD5_HUMANUBA1_HUMANBioGRID, MINT21900206 details
SMAD5_HUMANSF3B3_HUMANBioGRID, MINT21900206 details
SMAD5_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
SMAD5_HUMANWBP2_HUMANBioGRID, IntAct32296183 details
SMAD5_HUMANKLK6_HUMANIntAct32814053 details
SMAD5_HUMANLITAF_HUMANIntAct32814053 details
SMAD5_HUMANPKHO1_HUMANBioGRID18641638 details
SMAD5_HUMANEP300_HUMANBioGRID16516194 16613856 details
SMAD5_HUMANSUV91_HUMANBioGRID, HPRD15107829 details
SMAD5_HUMANCSN5_HUMANBioGRID17133595 details
SMAD5_HUMANHGS_HUMANBioGRID16516194 details
SMAD5_HUMANZNF8_HUMANHPRD12370310 details
SMAD5_HUMANFLNA_HUMANHPRD11278410 details
SMAD5_HUMANZEB2_HUMANHPRD10400677 12714599 details
SMAD5_HUMANHXA13_HUMANHPRD16087734 details
SMAD5_HUMANMBD1_HUMANHPRD15231748 details
SMAD5_HUMANRUNX2_HUMANBioGRID, Molecular Connections10531362 22966907 details
SMAD5_HUMANDDX5_HUMANDIP18548003 details
SMAD5_HUMANTOB1_HUMANBioGRID, HPRD11163184 details
SMAD5_HUMANRUNX1_HUMANBioGRID10531362 details
SMAD5_HUMANRUNX3_HUMANBioGRID10531362 details
SMAD5_HUMANACVR1_HUMANBioGRID, HPRD10583507 10652350 9748228 details
SMAD5_HUMANHMGA2_HUMANBioGRID18425117 details
SMAD5_HUMANSUV92_HUMANBioGRID, HPRD15107829 details
SMAD5_HUMANKAT2A_HUMANBioGRID15009097 details
SMAD5_HUMANSKI_HUMANBioGRID14699069 details
SMAD5_HUMANHDAC1_HUMANBioGRID14699069 details
SMAD5_HUMANCHIP_HUMANBioGRID21454478 details
SMAD5_HUMANMEN1_HUMANBioGRID, HPRD12649288 details
SMAD5_HUMANCDK8_HUMANBioGRID19914168 details
SMAD5_HUMANYAP1_HUMANBioGRID19914168 details
SMAD5_HUMANSMAD6_HUMANBioGRID12857866 details
SMAD5_HUMANPAX6_HUMANBioGRID17251190 details
SMAD5_HUMANBMP6_HUMANHPRD10504300 details
SMAD5_HUMANGDF6_HUMANHPRD15246821 details