Entity Details

Primary name IFIH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BYX4
EntryNameIFIH1_HUMAN
FullNameInterferon-induced helicase C domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length1025
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesIFIH1

GO terms

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GOName
GO:0003677 DNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008270 zinc ion binding
GO:0009597 detection of virus
GO:0009615 response to virus
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0016787 hydrolase activity
GO:0016925 protein sumoylation
GO:0032480 negative regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034344 regulation of type III interferon production
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus
GO:0039530 MDA-5 signaling pathway
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0098586 cellular response to virus

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR021673 RIG-I-like receptor, C-terminal regulatory domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031964 Caspase recruitment domainDomainDomain
IPR038557 RIG-I-like receptor, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041204 RIG-I receptor, C-terminalDomainDomain

Diseases

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