Entity Details

Primary name FOXP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZS1
EntryNameFOXP3_HUMAN
FullNameForkhead box protein P3
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesFOXP3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001782 B cell homeostasis
GO:0001818 negative regulation of cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
GO:0002456 T cell mediated immunity
GO:0002513 tolerance induction to self antigen
GO:0002667 regulation of T cell anergy
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0014045 establishment of endothelial blood-brain barrier
GO:0030111 regulation of Wnt signaling pathway
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0032991 protein-containing complex
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0035035 histone acetyltransferase binding
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043029 T cell homeostasis
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045589 regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046007 negative regulation of activated T cell proliferation
GO:0046872 metal ion binding
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050687 negative regulation of defense response to virus
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0051059 NF-kappaB binding
GO:0051525 NFAT protein binding
GO:1901355 response to rapamycin
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032354 FOXP, coiled-coil domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
FOXP3_HUMANPR20C_HUMANBioGRID, IntAct25416956 25910212 29892012 32296183 details
FOXP3_HUMANRBPMS_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 details
FOXP3_HUMANPIM1_HUMANIntAct25096571 details
FOXP3_HUMANCHIP_HUMANBioGRID, IntAct23973223 33209884 details
FOXP3_HUMANRUNX1_HUMANBioGRID, DIP, HPRD17377532 details
FOXP3_HUMANRORA_HUMANIntAct18354202 details
FOXP3_HUMANPR20D_HUMANBioGRID, IntAct25416956 25910212 29892012 32296183 details
FOXP3_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
FOXP3_HUMANPR20E_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
FOXP3_HUMANIKZF4_HUMANBioGRID19696312 details
FOXP3_HUMANKAT8_HUMANBioGRID22152480 details
FOXP3_HUMANPR20B_HUMANBioGRID25416956 25910212 29892012 32296183 details
FOXP3_HUMANPR20A_HUMANBioGRID25416956 25910212 29892012 32296183 details
FOXP3_HUMANSIVA_HUMANBioGRID21955384 details
FOXP3_HUMANEP300_HUMANBioGRID16652169 19996091 details
FOXP3_HUMANNLK_HUMANBioGRID30917315 details
FOXP3_HUMANMDM2_HUMANBioGRID32636834 details
FOXP3_HUMANIKZF3_HUMANBioGRID, InnateDB20676092 details
FOXP3_HUMANHDAC2_HUMANBioGRID, MINT19276356 25609649 details
FOXP3_HUMANPP1A_HUMANIntAct23396208 details
FOXP3_HUMANREL_HUMANBioGRID, IntAct20064449 21490927 details
FOXP3_HUMANHDAC1_HUMANBioGRID, IntAct21974802 24944246 details
FOXP3_HUMANNFAC2_HUMANBioGRID, HPRD, IntAct15790681 16517728 19564342 details
FOXP3_HUMANRORG_HUMANDIP18368049 details
FOXP3_HUMANTF65_HUMANBioGRID, IntAct15790681 25712342 details
FOXP3_HUMANZFP90_HUMANIntAct23543754 details
FOXP3_HUMANKAT5_HUMANBioGRID, DIP17360565 19996091 details
FOXP3_HUMANHDAC7_HUMANBioGRID, DIP17360565 details
FOXP3_HUMANHDAC9_HUMANBioGRID, DIP17360565 details
FOXP3_HUMANUBP44_HUMANBioGRID, MINT32644293 details
FOXP3_HUMANHDAC4_HUMANBioGRID19276356 details
FOXP3_HUMANNFAC1_HUMANBioGRID15790681 21490927 details
FOXP3_HUMANH15_HUMANBioGRID21654845 details
FOXP3_HUMANGATA3_HUMANBioGRID23395819 details
FOXP3_HUMANSIR1_HUMANBioGRID19996091 details
FOXP3_HUMANUBP7_HUMANBioGRID30917315 details
FOXP3_HUMANNFAT5_HUMANHPRD15790681 details