Entity Details

Primary name AMRA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C0C7
EntryNameAMRA1_HUMAN
FullNameActivating molecule in BECN1-regulated autophagy protein 1
TaxID9606
Evidenceevidence at protein level
Length1298
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesAMBRA1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000422 autophagy of mitochondrion
GO:0000423 mitophagy
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005930 axoneme
GO:0006914 autophagy
GO:0008285 negative regulation of cell population proliferation
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0016236 macroautophagy
GO:0021915 neural tube development
GO:0030154 cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0051020 GTPase binding
GO:0098780 response to mitochondrial depolarisation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
AMRA1_HUMANBECN1_HUMANBioGRID, DIP, HPRD, IntAct, MINT17589504 20562859 20711182 20921139 21358617 23954414 23974797 24587252 25438055 25499913 30258449 details
AMRA1_HUMANBCL2_HUMANBioGRID, MINT21358617 details
AMRA1_HUMANCUL4A_HUMANBioGRID, IntAct16949367 19295130 21145461 25499913 30166453 31155351 31973889 details
AMRA1_HUMANCUL4B_HUMANBioGRID, IntAct16949367 21145461 25499913 30166453 31155351 31973889 details
AMRA1_HUMANDYL1_HUMANBioGRID, IntAct20921139 27173435 30166453 unassigned1312 details
AMRA1_HUMANULK1_HUMANBioGRID, DIP20921139 23524951 25438055 details
AMRA1_HUMANPP2AA_HUMANBioGRID, DIP25438055 details
AMRA1_HUMANMTOR_HUMANBioGRID23524951 details
AMRA1_HUMANUB2D3_HUMANBioGRID23974797 details
AMRA1_HUMANRING2_HUMANBioGRID24980959 details
AMRA1_HUMANGBRAP_HUMANBioGRID25215947 30217973 details
AMRA1_HUMANMLP3B_HUMANBioGRID30217973 details
AMRA1_HUMANMLP3A_HUMANBioGRID27875637 30217973 details
AMRA1_HUMANMLP3C_HUMANBioGRID30217973 details
AMRA1_HUMANGBRL1_HUMANBioGRID30217973 details
AMRA1_HUMANGBRL2_HUMANBioGRID30217973 details
AMRA1_HUMANIKKA_HUMANBioGRID30217973 details
AMRA1_HUMANSYUA_HUMANBioGRID27875637 details
AMRA1_HUMANDDA1_HUMANBioGRID, IntAct19295130 20562859 25499913 30166453 31155351 details
AMRA1_HUMANDDB1_HUMANBioGRID, IntAct16949367 20562859 25499913 30166453 31155351 33854235 details
AMRA1_HUMANNUDC_HUMANIntAct25036637 details
AMRA1_HUMANDCAF7_HUMANBioGRID, IntAct27173435 30166453 unassigned1312 details
AMRA1_HUMANDYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
AMRA1_HUMANSOCS3_HUMANBioGRID, IntAct28514442 30166453 details
AMRA1_HUMANRPTOR_HUMANBioGRID, DIP23524951 details
AMRA1_HUMANTRAF6_HUMANBioGRID, DIP23524951 25499913 details
AMRA1_HUMANMYC_HUMANBioGRID, DIP25438055 29467282 details
AMRA1_HUMAN2AAA_HUMANBioGRID, DIP25438055 details
AMRA1_HUMANPRKN_HUMANBioGRID21753002 24879156 details
AMRA1_HUMANDC1I1_HUMANBioGRID20921139 details
AMRA1_HUMANPK3C3_HUMANBioGRID20921139 details
AMRA1_HUMANSGT1_HUMANBioGRID25499913 details
AMRA1_HUMANELOB_HUMANBioGRID25499913 27875637 30166453 31253590 details
AMRA1_HUMANCUL7_HUMANBioGRID25499913 details
AMRA1_HUMANIRGM_HUMANBioGRID25891078 details
AMRA1_HUMANSOCS2_HUMANBioGRID28883622 30166453 details
AMRA1_HUMANHUWE1_HUMANBioGRID30217973 details
AMRA1_HUMANELOC_HUMANBioGRID30166453 details
AMRA1_HUMANTRI32_HUMANBioGRID31123703 details
AMRA1_HUMANSTABP_HUMANBioGRID32453962 details
AMRA1_HUMANCCND1_HUMANBioGRID33854235 details