Entity Details

Primary name ING2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H160
EntryNameING2_HUMAN
FullNameInhibitor of growth protein 2
TaxID9606
Evidenceevidence at protein level
Length280
SequenceStatuscomplete
DateCreated2005-02-15
DateModified2021-06-02

Ontological Relatives

GenesING2

GO terms

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GOName
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0007141 male meiosis I
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008285 negative regulation of cell population proliferation
GO:0016580 Sin3 complex
GO:0016602 CCAAT-binding factor complex
GO:0030317 flagellated sperm motility
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031065 positive regulation of histone deacetylation
GO:0035064 methylated histone binding
GO:0035091 phosphatidylinositol binding
GO:0040008 regulation of growth
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048133 male germ-line stem cell asymmetric division
GO:0072520 seminiferous tubule development
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000772 regulation of cellular senescence
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR024610 Inhibitor of growth protein, N-terminal histone-bindingDomainDomain
IPR028639 Inhibitor of growth protein 2FamilyFamily
IPR028651 ING familyFamilyFamily
IPR042019 ING2, PHD domainDomainDomain

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ING2_HUMANPCNA_HUMANBioGRID, MINT19730436 details
ING2_HUMANSMUF1_HUMANBioGRID, HPRD, MINT15761153 20621832 details
ING2_HUMANCSN2_HUMANBioGRID17929852 details
ING2_HUMANA4_HUMANBioGRID21244100 21832049 details
ING2_HUMANH31T_HUMANBioGRID20953165 22595675 details
ING2_HUMANP53_HUMANBioGRID, MINT16024799 16782091 details
ING2_HUMANEP300_HUMANBioGRID, HPRD, MINT16024799 16782091 details
ING2_HUMANUBC_HUMANMINT20621832 details
ING2_HUMANSIN3A_HUMANBioGRID, I2D, IntAct16387653 16728974 20676127 28514442 details
ING2_HUMANSUMO1_HUMANI2D20676127 details
ING2_HUMANH33_HUMANMINT20953165 details
ING2_HUMANHDAC1_HUMANBioGRID, IntAct16387653 16728974 18193082 23752268 28514442 details
ING2_HUMANSAP30_HUMANBioGRID, IntAct16387653 26496610 28514442 details
ING2_HUMANSDS3_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANSP130_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANHDAC2_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANBRM1L_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANARI4B_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANRBBP7_HUMANBioGRID, IntAct16387653 26186194 28514442 details
ING2_HUMANARI4A_HUMANBioGRID, IntAct16387653 28514442 details
ING2_HUMANRBBP4_HUMANBioGRID16387653 details
ING2_HUMANSMRC2_HUMANBioGRID16387653 details
ING2_HUMANSMRC1_HUMANBioGRID16387653 details
ING2_HUMANACL6A_HUMANBioGRID16387653 details
ING2_HUMANSNF5_HUMANBioGRID16387653 details
ING2_HUMANSKIL_HUMANBioGRID18334480 details
ING2_HUMANSMAD2_HUMANBioGRID18334480 details
ING2_HUMANSIR1_HUMANBioGRID18193082 details
ING2_HUMANWDR5_HUMANBioGRID22689669 details
ING2_HUMANANM5_HUMANBioGRID22689669 details
ING2_HUMANH4_HUMANBioGRID, HPRD16782091 30804502 details
ING2_HUMANSMAD1_HUMANHPRD15761153 details
ING2_HUMANSMUF2_HUMANHPRD15761153 details