Entity Details

Primary name BIRC5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15392
EntryNameBIRC5_HUMAN
FullNameBaculoviral IAP repeat-containing protein 5
TaxID9606
Evidenceevidence at protein level
Length142
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBIRC5

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000228 nuclear chromosome
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007605 sensory perception of sound
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0015631 tubulin binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030496 midbody
GO:0031021 interphase microtubule organizing center
GO:0031267 small GTPase binding
GO:0031503 protein-containing complex localization
GO:0031536 positive regulation of exit from mitosis
GO:0032133 chromosome passenger complex
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050897 cobalt ion binding
GO:0051087 chaperone binding
GO:0051301 cell division
GO:0051303 establishment of chromosome localization
GO:0051726 regulation of cell cycle

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR001370 BIR repeatRepeatRepeat

Diseases

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Drugs

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DrugNameSourceType
DB00206 ReserpineDrugbanksmall molecule
DB04115 BerberineDrugbanksmall molecule
DB05141 LY2181308Drugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
BIRC5_HUMANBIRC5_HUMANBioGRID, HPRD, IntAct, MINT10876248 10949039 11170436 14699067 15688031 16291752 16571674 17099693 21536684 23251006 details
BIRC5_HUMANAURKB_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11516652 12419797 16291752 17099693 17681274 18477699 19357306 19951914 19995937 20430883 21051298 21554500 23945651 24571573 27332895 29568061 31586073 32738097 details
BIRC5_HUMANCASP7_HUMANBioGRID, HPRD11024045 11170436 9850056 details
BIRC5_HUMANINCE_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11516652 16239925 16571674 17099693 17956729 19951914 21051298 21225229 28514442 details
BIRC5_HUMANEVI5_HUMANBioGRID16764853 details
BIRC5_HUMANBOREA_HUMANBioGRID, DIP, HPRD, IntAct, MINT15249581 15260989 16291752 16571674 17099693 17956729 18243099 18946085 20430883 20739936 21051298 23945651 26186194 28514442 details
BIRC5_HUMANXIAP_HUMANBioGRID, HPRD, Molecular Connections15218035 17613533 21536684 24083380 details
BIRC5_HUMANDBLOH_HUMANBioGRID, HPRD, IntAct12660240 14699067 15541727 21536684 23251006 details
BIRC5_HUMANCC85B_HUMANBioGRID, IntAct32296183 details
BIRC5_HUMANLTOR5_HUMANBioGRID28807996 30692632 32296183 details
BIRC5_HUMANCASP3_HUMANBioGRID, HPRD11170436 9850056 details
BIRC5_HUMANFBXL7_HUMANBioGRID25778398 28218735 details
BIRC5_HUMANRAN_HUMANBioGRID, IntAct23251006 details
BIRC5_HUMANBIRC2_HUMANBioGRID15218035 15665297 25635055 details
BIRC5_HUMANH32_HUMANBioGRID20929775 details
BIRC5_HUMANAURKA_HUMANBioGRID, DIP19357306 details
BIRC5_HUMANAPBB2_HUMANIntAct32814053 details
BIRC5_HUMANXPO1_HUMANBioGRID, HPRD, MINT17099693 details
BIRC5_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
BIRC5_HUMANOGT1_HUMANBioGRID32994395 details
BIRC5_HUMANAURKC_HUMANBioGRID, IntAct, UniProt21988832 27332895 details
BIRC5_HUMANOPTN_HUMANIntAct32814053 details
BIRC5_HUMANPEX26_HUMANIntAct32814053 details
BIRC5_HUMANKCNJ6_HUMANBioGRID15218035 details
BIRC5_HUMANH31T_HUMANBioGRID23281010 details
BIRC5_HUMANHD_HUMANIntAct32814053 details
BIRC5_HUMANTADBP_HUMANIntAct32814053 details
BIRC5_HUMANBIRC3_HUMANBioGRID15218035 details
BIRC5_HUMANDCTN1_HUMANIntAct32814053 details
BIRC5_HUMANGDAP1_HUMANIntAct32814053 details
BIRC5_HUMANSYUA_HUMANIntAct32814053 details
BIRC5_HUMANA4_HUMANIntAct32814053 details
BIRC5_HUMANUCHL1_HUMANIntAct32814053 details
BIRC5_HUMANPINK1_HUMANIntAct32814053 details
BIRC5_HUMANCDK1_HUMANHPRD, IntAct11069302 11861764 17681274 details
BIRC5_HUMANAIP_HUMANBioGRID19366855 details
BIRC5_HUMANCASP9_HUMANBioGRID, HPRD, IntAct, MINT11024045 11069302 25241761 details
BIRC5_HUMANCDK4_HUMANBioGRID, HPRD10713676 details
BIRC5_HUMANGA2L3_HUMANMINT24571573 details
BIRC5_HUMANH2AX_HUMANBioGRID20394854 details
BIRC5_HUMANHDAC6_HUMANBioGRID22334690 details
BIRC5_HUMANHS90A_HUMANBioGRID, HPRD15894266 details
BIRC5_HUMANCSN5_HUMANBioGRID29596838 details
BIRC5_HUMANCDK2_HUMANBioGRID11069302 details
BIRC5_HUMANUSP9X_HUMANBioGRID16322459 details
BIRC5_HUMANPRKN_HUMANBioGRID26148234 details
BIRC5_HUMANRASA1_HUMANHPRD11976319 details
BIRC5_HUMANBECN1_HUMANBioGRID, MINT20638385 26148234 details
BIRC5_HUMANUFD1_HUMANBioGRID16322459 details
BIRC5_HUMANBIRC6_HUMANHPRD18329369 details
BIRC5_HUMANPRKDC_HUMANBioGRID20394854 details
BIRC5_HUMANMDC1_HUMANBioGRID20394854 details
BIRC5_HUMANSTALP_HUMANBioGRID31817770 details
BIRC5_HUMANUBP22_HUMANBioGRID32973959 details
BIRC5_HUMANATG5_HUMANBioGRID23945651 details
BIRC5_HUMANXRCC6_HUMANBioGRID20394854 details
BIRC5_HUMANPAR2_HUMANBioGRID20826780 details