Entity Details

Primary name SMUF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HAU4
EntryNameSMUF2_HUMAN
FullNameE3 ubiquitin-protein ligase SMURF2
TaxID9606
Evidenceevidence at protein level
Length748
SequenceStatuscomplete
DateCreated2001-12-13
DateModified2021-06-02

Ontological Relatives

GenesSMURF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061630 ubiquitin protein ligase activity
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901165 positive regulation of trophoblast cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane raft
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

158 interactions

InteractorPartnerSourcesPublicationsLink
SMUF2_HUMANRNF11_HUMANBioGRID, HPRD, I2D, IntAct, MINT14562029 14755250 15231748 20676133 28292929 31985874 details
SMUF2_HUMANUBB_HUMANIntAct14755250 17719543 details
SMUF2_HUMANSMAD2_HUMANBioGRID, DIP, HPRD, IntAct, MINT11016919 11158580 11389444 15221015 15231748 18729074 19122240 19620243 20937913 22045334 28468752 28881580 details
SMUF2_HUMANTRAF4_HUMANBioGRID, HPRD, MINT15231748 23973329 details
SMUF2_HUMANDAZP2_HUMANBioGRID, HPRD, MINT15231748 22070932 details
SMUF2_HUMANFLNB_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANTNPO3_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANSMUF2_HUMANBioGRID, HPRD, IntAct, MINT15231748 16061177 17719543 17996703 20858899 23973329 25438670 26949039 27086113 28292929 28611047 29463679 29964046 30021006 30587574 31628949 details
SMUF2_HUMANSMAD7_HUMANBioGRID, DIP, HPRD, MINT11163210 14722617 15221015 15231748 16061177 16641086 17719543 18448069 20937913 22624557 22773947 22921829 23973329 26435193 26679521 27292644 28292929 29235476 32283253 details
SMUF2_HUMANSMAD5_HUMANBioGRID, HPRD, IntAct, MINT15221015 15231748 20484049 28514442 details
SMUF2_HUMANSPART_HUMANBioGRID, HPRD, MINT15231748 19307600 details
SMUF2_HUMANTFPI2_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANCALX_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANCUED1_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANRHG05_HUMANBioGRID, HPRD, IntAct, MINT15231748 28514442 details
SMUF2_HUMANTXNIP_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANDAB2_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANSMAD6_HUMANBioGRID, HPRD, MINT15221015 15231748 15761153 24850914 details
SMUF2_HUMANIDD_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANABRX2_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANGCP60_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANSF3A2_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANACOX3_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANRN111_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANTM139_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANRU17_HUMANBioGRID, HPRD, MINT15231748 details
SMUF2_HUMANSMAD1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11016919 11158580 14701756 15221015 15231748 20937913 28468752 28514442 32296183 details
SMUF2_HUMANRHOA_HUMANBioGRID, IntAct17719543 20026602 21402695 details
SMUF2_HUMANNEBL_HUMANMINT18157088 details
SMUF2_HUMANTNNI3_HUMANMINT18157088 details
SMUF2_HUMANDESM_HUMANMINT18157088 details
SMUF2_HUMANTITIN_HUMANMINT18157088 details
SMUF2_HUMANCCAR1_HUMANMINT18157088 details
SMUF2_HUMANFLNC_HUMANMINT18157088 details
SMUF2_HUMANFHL2_HUMANMINT18157088 details
SMUF2_HUMANGMEB1_HUMANMINT18157088 details
SMUF2_HUMANEF1G_HUMANMINT18157088 details
SMUF2_HUMANECHM_HUMANMINT18157088 details
SMUF2_HUMANEFGM_HUMANMINT18157088 details
SMUF2_HUMANUXT_HUMANMINT18157088 details
SMUF2_HUMANEIF3E_HUMANMINT18157088 details
SMUF2_HUMANDCAF6_HUMANMINT18157088 details
SMUF2_HUMANRM02_HUMANMINT18157088 details
SMUF2_HUMANSQSTM_HUMANMINT18157088 details
SMUF2_HUMANNOMO1_HUMANMINT18157088 details
SMUF2_HUMANATPB_HUMANMINT18157088 details
SMUF2_HUMANMYPC3_HUMANMINT18157088 details
SMUF2_HUMANRM19_HUMANMINT18157088 details
SMUF2_HUMANNDUA1_HUMANMINT18157088 details
SMUF2_HUMANTELT_HUMANMINT18157088 details
SMUF2_HUMANACTS_HUMANMINT18157088 details
SMUF2_HUMANTNNT1_HUMANMINT18157088 details
SMUF2_HUMANNEBU_HUMANMINT18157088 details
SMUF2_HUMANTNNI2_HUMANMINT18157088 details
SMUF2_HUMANMYOZ1_HUMANMINT18157088 details
SMUF2_HUMANLMCD1_HUMANMINT18157088 details
SMUF2_HUMANRM41_HUMANMINT18157088 details
SMUF2_HUMANUBC_HUMANBioGRID, MINT19343052 23644597 23973329 25438670 25723849 28881580 29964046 31628949 details
SMUF2_HUMANSMAD3_HUMANBioGRID, HPRD, IntAct, MINT11016919 11158580 11389444 15221015 18729074 19122240 22045334 23973329 28839186 28881580 32296183 details
SMUF2_HUMANFXL15_HUMANBioGRID, MINT21572392 details
SMUF2_HUMANRT4I1_HUMANBioGRID, IntAct32296183 details
SMUF2_HUMANNEDD4_HUMANBioGRID, DIP, IntAct15496141 25438670 28514442 details
SMUF2_HUMANTTC3_HUMANBioGRID, UniProt30696809 details
SMUF2_HUMANAIMP1_HUMANBioGRID18448069 details
SMUF2_HUMANUB2L3_HUMANBioGRID16061177 17719543 17996703 20858899 25723849 26949039 27182664 29263404 29964046 30587574 31628949 details
SMUF2_HUMANID1_HUMANBioGRID21933340 details
SMUF2_HUMANID3_HUMANBioGRID21933340 details
SMUF2_HUMANKLF5_HUMANBioGRID21953463 details
SMUF2_HUMANEGFR_HUMANBioGRID21750651 32669362 details
SMUF2_HUMANBRE1A_HUMANBioGRID22231558 details
SMUF2_HUMANAXIN1_HUMANBioGRID20858899 details
SMUF2_HUMANRUNX2_HUMANBioGRID21402695 details
SMUF2_HUMANRNF12_HUMANBioGRID21945933 details
SMUF2_HUMANUBP15_HUMANBioGRID22344298 26435193 details
SMUF2_HUMANUB2D1_HUMANBioGRID20858899 24709419 25723849 32669362 details
SMUF2_HUMANUB2D3_HUMANBioGRID20484049 20858899 21402695 23644597 25438670 25723849 28611047 30021006 details
SMUF2_HUMANMAVS_HUMANBioGRID24729608 details
SMUF2_HUMANFBW1A_HUMANBioGRID24709419 details
SMUF2_HUMANTYY1_HUMANBioGRID24803334 details
SMUF2_HUMANLATS1_HUMANBioGRID24107629 details
SMUF2_HUMANUB2D2_HUMANBioGRID25723849 27182664 details
SMUF2_HUMANANM1_HUMANBioGRID26126536 details
SMUF2_HUMANAIMP2_HUMANBioGRID27197155 details
SMUF2_HUMANFUBP1_HUMANBioGRID27197155 details
SMUF2_HUMANXPO1_HUMANBioGRID27197155 details
SMUF2_HUMANNEDD8_HUMANBioGRID28169289 details
SMUF2_HUMANITBP1_HUMANBioGRID28049720 details
SMUF2_HUMANTOP2A_HUMANBioGRID28611047 details
SMUF2_HUMANPDE4B_HUMANBioGRID29100790 details
SMUF2_HUMANLMNA_HUMANBioGRID29405587 details
SMUF2_HUMANCNKR2_HUMANBioGRID29534682 details
SMUF2_HUMANSYUA_HUMANBioGRID30021006 details
SMUF2_HUMANSIR1_HUMANBioGRID32361710 details
SMUF2_HUMANZBT44_HUMANHPRD15231748 details
SMUF2_HUMANPAR6A_HUMANIntAct19379695 details
SMUF2_HUMANSMUF1_HUMANBioGRID, IntAct18927080 21897371 27086113 28514442 details
SMUF2_HUMANTGFR1_HUMANBioGRID, HPRD11163210 14722617 21791611 22624557 23973329 25149540 26679521 31746425 details
SMUF2_HUMANTGFR2_HUMANBioGRID11163210 25149540 details
SMUF2_HUMANSKIL_HUMANBioGRID, HPRD11389444 details
SMUF2_HUMANTRAF2_HUMANBioGRID, HPRD18671942 details
SMUF2_HUMANTNR1B_HUMANBioGRID18671942 details
SMUF2_HUMANRUNX3_HUMANBioGRID, HPRD15138260 details
SMUF2_HUMANGSK3B_HUMANBioGRID19481076 details
SMUF2_HUMANCCM2_HUMANBioGRID19318350 details
SMUF2_HUMANHSPB1_HUMANBioGRID21967197 details
SMUF2_HUMANEFNB1_HUMANBioGRID23475958 details
SMUF2_HUMANSMAD4_HUMANBioGRID23973329 28468752 details
SMUF2_HUMANPTC1_HUMANBioGRID25092867 details
SMUF2_HUMANUBC9_HUMANBioGRID26679521 details
SMUF2_HUMANPIAS3_HUMANBioGRID26679521 details
SMUF2_HUMANGLIS3_HUMANBioGRID26147758 details
SMUF2_HUMANCASL_HUMANBioGRID20825672 details
SMUF2_HUMANSETD7_HUMANBioGRID27292644 details
SMUF2_HUMANSKI_HUMANBioGRID28468752 details
SMUF2_HUMANNADC_HUMANBioGRID28724915 details
SMUF2_HUMANUBC12_HUMANBioGRID27086113 details
SMUF2_HUMANPKHD1_HUMANBioGRID28798345 details
SMUF2_HUMANFMN2_HUMANBioGRID29659741 details
SMUF2_HUMANDVL2_HUMANBioGRID29659741 details
SMUF2_HUMANEZH2_HUMANBioGRID30649914 31948940 details
SMUF2_HUMANSATB1_HUMANBioGRID30742943 details
SMUF2_HUMANBRAF_HUMANBioGRID31015455 details
SMUF2_HUMANH2AX_HUMANBioGRID31533041 details
SMUF2_HUMANMLXPL_HUMANBioGRID31409643 details
SMUF2_HUMANPARP1_HUMANBioGRID32167680 details
SMUF2_HUMANRS27A_HUMANHPRD14755250 details
SMUF2_HUMANAPC5_HUMANHPRD15761153 details
SMUF2_HUMANASH2L_HUMANHPRD15761153 details
SMUF2_HUMANEPHA1_HUMANHPRD15761153 details
SMUF2_HUMANFKBP4_HUMANHPRD15761153 details
SMUF2_HUMANGBG2_HUMANHPRD15761153 details
SMUF2_HUMANHDGR3_HUMANHPRD15761153 details
SMUF2_HUMANING2_HUMANHPRD15761153 details
SMUF2_HUMANIRF3_HUMANHPRD15761153 details
SMUF2_HUMANIRF8_HUMANHPRD15761153 details
SMUF2_HUMANNEK6_HUMANHPRD15761153 details
SMUF2_HUMANKBRS1_HUMANHPRD15761153 details
SMUF2_HUMANRASN_HUMANHPRD15761153 details
SMUF2_HUMANPPID_HUMANHPRD15761153 details
SMUF2_HUMANRAB13_HUMANHPRD15761153 details
SMUF2_HUMANRAB14_HUMANHPRD15761153 details
SMUF2_HUMANRAB17_HUMANHPRD15761153 details
SMUF2_HUMANRB22A_HUMANHPRD15761153 details
SMUF2_HUMANRAB25_HUMANHPRD15761153 details
SMUF2_HUMANRAN_HUMANHPRD15761153 details
SMUF2_HUMANRHES_HUMANHPRD15761153 details
SMUF2_HUMANRASLC_HUMANHPRD15761153 details
SMUF2_HUMANRHOD_HUMANHPRD15761153 details
SMUF2_HUMANRING2_HUMANHPRD15761153 details
SMUF2_HUMANRRAS2_HUMANHPRD15761153 details
SMUF2_HUMANSRSF4_HUMANHPRD15761153 details
SMUF2_HUMANSMAP1_HUMANHPRD15761153 details
SMUF2_HUMANSOCS6_HUMANHPRD15761153 details
SMUF2_HUMANTSSK4_HUMANHPRD15761153 details
SMUF2_HUMANRAP1B_HUMANHPRD17318188 details
SMUF2_HUMANPRIC1_HUMANHPRD19379695 details
SMUF2_HUMANPRIC2_HUMANHPRD19379695 details