Entity Details

Primary name CISH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NSE2
EntryNameCISH_HUMAN
FullNameCytokine-inducible SH2-containing protein
TaxID9606
Evidenceevidence at protein level
Length258
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesCISH

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043687 post-translational protein modification
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028425 Cytokine-inducible SH2-containing proteinFamilyFamily
IPR035887 CIS, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
CISH_HUMANEPOR_HUMANBioGRID, HPRD, MINT11781573 15644415 16961462 28038963 7796808 9774439 details
CISH_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
CISH_HUMANERBB2_HUMANBioGRID, MINT16273093 details
CISH_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 24658140 25402006 31980649 details
CISH_HUMANETV5_HUMANBioGRID, IntAct21988832 details
CISH_HUMANHSP76_HUMANBioGRID, IntAct21988832 details
CISH_HUMANM3KCL_HUMANBioGRID, IntAct21988832 details
CISH_HUMANTPP1_HUMANIntAct32814053 details
CISH_HUMANDYN2_HUMANIntAct32814053 details
CISH_HUMANCARTF_HUMANIntAct32814053 details
CISH_HUMANATX1_HUMANIntAct32814053 details
CISH_HUMANGHR_HUMANBioGRID, HPRD10585430 12586763 25505247 details
CISH_HUMANMYD88_HUMANBioGRID16961462 details
CISH_HUMANCSF3R_HUMANBioGRID, HPRD15470047 details
CISH_HUMANCUL5_HUMANBioGRID, IntAct16961462 18508766 26186194 28514442 31253590 details
CISH_HUMANIL2RB_HUMANBioGRID, HPRD10514520 details
CISH_HUMANIL3RA_HUMANBioGRID, HPRD7796808 details
CISH_HUMANELOB_HUMANBioGRID16961462 31253590 details
CISH_HUMANELOC_HUMANBioGRID16961462 details
CISH_HUMANB2L11_HUMANBioGRID18420585 19622774 details
CISH_HUMANCCNE1_HUMANBioGRID18508766 details
CISH_HUMANCCNC_HUMANBioGRID18508766 details
CISH_HUMANRACK1_HUMANBioGRID18420585 details
CISH_HUMANCUL2_HUMANBioGRID18420585 details
CISH_HUMANLCK_HUMANBioGRID21234523 details
CISH_HUMANUBC_HUMANBioGRID25448846 details
CISH_HUMANIL7RA_HUMANBioGRID27423467 27596538 details
CISH_HUMANPLCG1_HUMANBioGRID29593227 details
CISH_HUMANPRLR_HUMANHPRD11713228 details
CISH_HUMANKPCA_HUMANHPRD12618484 details
CISH_HUMANKPCB_HUMANHPRD12618484 details
CISH_HUMANKPCT_HUMANHPRD12618484 details
CISH_HUMANIL3RB_HUMANHPRD7796808 details
CISH_HUMANKIT_HUMANHPRD14707129 details