Entity Details

Primary name SPHK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NYA1
EntryNameSPHK1_HUMAN
FullNameSphingosine kinase 1
TaxID9606
Evidenceevidence at protein level
Length384
SequenceStatuscomplete
DateCreated2001-10-24
DateModified2021-06-02

Ontological Relatives

GenesSPHK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001568 blood vessel development
GO:0001727 lipid kinase activity
GO:0003677 DNA binding
GO:0003951 NAD+ kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006457 protein folding
GO:0006473 protein acetylation
GO:0006665 sphingolipid metabolic process
GO:0006670 sphingosine metabolic process
GO:0006954 inflammatory response
GO:0007420 brain development
GO:0008289 lipid binding
GO:0008481 sphinganine kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0016407 acetyltransferase activity
GO:0017050 D-erythro-sphingosine kinase activity
GO:0019722 calcium-mediated signaling
GO:0030100 regulation of endocytosis
GO:0030139 endocytic vesicle
GO:0030148 sphingolipid biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031398 positive regulation of protein ubiquitination
GO:0031901 early endosome membrane
GO:0032651 regulation of interleukin-1 beta production
GO:0032740 positive regulation of interleukin-17 production
GO:0034612 response to tumor necrosis factor
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045931 positive regulation of mitotic cell cycle
GO:0045987 positive regulation of smooth muscle contraction
GO:0046512 sphingosine biosynthetic process
GO:0046521 sphingoid catabolic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050764 regulation of phagocytosis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051721 protein phosphatase 2A binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071363 cellular response to growth factor stimulus
GO:0071897 DNA biosynthetic process
GO:0098793 presynapse
GO:0150077 regulation of neuroinflammatory response
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903978 regulation of microglial cell activation
GO:1905364 regulation of endosomal vesicle fusion

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Endosome membrane
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08868 FingolimodDrugbanksmall molecule