Entity Details

Primary name HTRA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43464
EntryNameHTRA2_HUMAN
FullNameSerine protease HTRA2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length458
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesHTRA2

GO terms

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GOName
GO:0000785 chromatin
GO:0004252 serine-type endopeptidase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006508 proteolysis
GO:0006672 ceramide metabolic process
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0007628 adult walking behavior
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 response to herbicide
GO:0009898 cytoplasmic side of plasma membrane
GO:0010822 positive regulation of mitochondrion organization
GO:0012501 programmed cell death
GO:0016020 membrane
GO:0016540 protein autoprocessing
GO:0019742 pentacyclic triterpenoid metabolic process
GO:0030900 forebrain development
GO:0031966 mitochondrial membrane
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0035458 cellular response to interferon-beta
GO:0035631 CD40 receptor complex
GO:0040014 regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 cellular protein catabolic process
GO:0045786 negative regulation of cell cycle
GO:0048666 neuron development
GO:0051082 unfolded protein binding
GO:0071300 cellular response to retinoic acid
GO:0071363 cellular response to growth factor stimulus
GO:0097194 execution phase of apoptosis
GO:1901215 negative regulation of neuron death
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903146 regulation of autophagy of mitochondrion
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization
GO:1905370 serine-type endopeptidase complex
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion intermembrane space
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR001940 Peptidase S1CFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
HTRA2_HUMANXIAP_HUMANBioGRID, HPRD, IntAct, MINT11583623 11602612 11604410 11606597 11801603 11803371 12865429 15201285 15300255 15781261 17906618 24698088 28642151 29631059 31470122 31617661 details
HTRA2_HUMANBIRC7_HUMANBioGRID, HPRD, IntAct11801603 26186194 28514442 details
HTRA2_HUMANUBP7_HUMANBioGRID, HPRD, IntAct16713569 details
HTRA2_HUMANNDUAD_HUMANBioGRID, IntAct17297443 31617661 details
HTRA2_HUMANPSN1_HUMANIntAct10971580 details
HTRA2_HUMANBIRC2_HUMANBioGRID, HPRD, IntAct11583623 11604410 12865429 28514442 31617661 details
HTRA2_HUMANBIRC3_HUMANBioGRID, HPRD, IntAct11583623 12865429 30948266 details
HTRA2_HUMANHTRA2_HUMANBioGRID, IntAct15201285 17266347 28642151 details
HTRA2_HUMANPHX2A_HUMANIntAct32814053 details
HTRA2_HUMANSHLB2_HUMANIntAct32814053 details
HTRA2_HUMANTEN1L_HUMANIntAct32814053 details
HTRA2_HUMANASIC4_HUMANIntAct32814053 details
HTRA2_HUMANZN444_HUMANIntAct32814053 details
HTRA2_HUMANPCMD2_HUMANIntAct32814053 details
HTRA2_HUMANTASO2_HUMANIntAct32814053 details
HTRA2_HUMANTTC19_HUMANBioGRID, IntAct31617661 32814053 details
HTRA2_HUMANOTULL_HUMANIntAct32814053 details
HTRA2_HUMANRBM11_HUMANIntAct32814053 details
HTRA2_HUMANRN138_HUMANIntAct32814053 details
HTRA2_HUMANKLF3_HUMANIntAct32814053 details
HTRA2_HUMANASB3_HUMANIntAct32814053 details
HTRA2_HUMANDCAF8_HUMANIntAct32814053 details
HTRA2_HUMANMYLIP_HUMANIntAct32814053 details
HTRA2_HUMANKLH20_HUMANIntAct32814053 details
HTRA2_HUMANPP16B_HUMANIntAct32814053 details
HTRA2_HUMANZN500_HUMANIntAct32814053 details
HTRA2_HUMANPATZ1_HUMANIntAct32814053 details
HTRA2_HUMANRYBP_HUMANIntAct32814053 details
HTRA2_HUMANHAUS7_HUMANIntAct32814053 details
HTRA2_HUMANWWP2_HUMANIntAct32814053 details
HTRA2_HUMANTNF15_HUMANIntAct32814053 details
HTRA2_HUMANFL2D_HUMANIntAct32814053 details
HTRA2_HUMANUBP2_HUMANIntAct32814053 details
HTRA2_HUMANEIF3F_HUMANIntAct32814053 details
HTRA2_HUMANPIAS1_HUMANIntAct32814053 details
HTRA2_HUMANZN232_HUMANIntAct32814053 details
HTRA2_HUMANZSC9_HUMANIntAct32814053 details
HTRA2_HUMANZBT25_HUMANIntAct32814053 details
HTRA2_HUMANSMN_HUMANIntAct32814053 details
HTRA2_HUMANSMRD1_HUMANIntAct32814053 details
HTRA2_HUMANPRS6A_HUMANIntAct32814053 details
HTRA2_HUMANNVL_HUMANIntAct32814053 details
HTRA2_HUMANNDF1_HUMANIntAct32814053 details
HTRA2_HUMANM3K5_HUMANIntAct32814053 details
HTRA2_HUMANKT33B_HUMANIntAct32814053 details
HTRA2_HUMANK1C19_HUMANIntAct32814053 details
HTRA2_HUMANID2_HUMANIntAct32814053 details
HTRA2_HUMANCRYA2_HUMANIntAct32814053 details
HTRA2_HUMANERCC8_HUMANIntAct32814053 details
HTRA2_HUMANOTUB1_HUMANIntAct32814053 details
HTRA2_HUMANASB9_HUMANIntAct32814053 details
HTRA2_HUMANKLC3_HUMANIntAct32814053 details
HTRA2_HUMANVP37A_HUMANIntAct32814053 details
HTRA2_HUMANPPR21_HUMANIntAct32814053 details
HTRA2_HUMANUSH1G_HUMANIntAct32814053 details
HTRA2_HUMANSOCS4_HUMANIntAct32814053 details
HTRA2_HUMANPIHD2_HUMANIntAct32814053 details
HTRA2_HUMANIFT20_HUMANIntAct32814053 details
HTRA2_HUMANMPND_HUMANIntAct32814053 details
HTRA2_HUMANKCD17_HUMANIntAct32814053 details
HTRA2_HUMANRUSF1_HUMANIntAct32814053 details
HTRA2_HUMANOTU7B_HUMANIntAct32814053 details
HTRA2_HUMANAN13D_HUMANIntAct32814053 details
HTRA2_HUMANENKUR_HUMANIntAct32814053 details
HTRA2_HUMANCENPV_HUMANIntAct32814053 details
HTRA2_HUMANLONF2_HUMANIntAct32814053 details
HTRA2_HUMANMARHA_HUMANIntAct32814053 details
HTRA2_HUMANSAMD3_HUMANIntAct32814053 details
HTRA2_HUMANRN183_HUMANIntAct32814053 details
HTRA2_HUMANMK14_HUMANBioGRID, HPRD10644717 17906618 details
HTRA2_HUMANBIRC6_HUMANBioGRID, HPRD15200957 15300255 15507451 15781261 31617661 details
HTRA2_HUMANLATS1_HUMANBioGRID16007220 17130845 22641346 details
HTRA2_HUMANAPC_HUMANBioGRID16007220 details
HTRA2_HUMANCASB_HUMANBioGRID, HPRD10971580 11583623 15201285 details
HTRA2_HUMANDBLOH_HUMANBioGRID, HPRD11604410 11606597 32877691 details
HTRA2_HUMANMK12_HUMANBioGRID17906618 details
HTRA2_HUMANMK11_HUMANBioGRID17906618 details
HTRA2_HUMANMK13_HUMANBioGRID17906618 details
HTRA2_HUMANMK03_HUMANBioGRID17906618 details
HTRA2_HUMANCDK1_HUMANBioGRID17906618 details
HTRA2_HUMANCDK5_HUMANBioGRID17906618 details
HTRA2_HUMANACTS_HUMANBioGRID17266347 details
HTRA2_HUMANTBA1A_HUMANBioGRID17266347 details
HTRA2_HUMANTBB5_HUMANBioGRID17266347 details
HTRA2_HUMANTBB6_HUMANBioGRID17266347 details
HTRA2_HUMANVIME_HUMANBioGRID17266347 details
HTRA2_HUMANAL1A2_HUMANBioGRID17266347 details
HTRA2_HUMANHCD2_HUMANBioGRID17266347 details
HTRA2_HUMANIF4G1_HUMANBioGRID17266347 details
HTRA2_HUMANEF1A1_HUMANBioGRID17266347 details
HTRA2_HUMANTIF1B_HUMANBioGRID17266347 details
HTRA2_HUMANPYR1_HUMANBioGRID17266347 details
HTRA2_HUMANVPS4B_HUMANBioGRID17266347 details
HTRA2_HUMANCCAR2_HUMANBioGRID17266347 details
HTRA2_HUMANPDXD1_HUMANBioGRID17266347 details
HTRA2_HUMANAREL1_HUMANBioGRID23479728 details
HTRA2_HUMANMUL1_HUMANBioGRID24709290 details
HTRA2_HUMANMIC60_HUMANBioGRID31617661 details
HTRA2_HUMANPHAG1_HUMANHPRD16413409 details
HTRA2_HUMANRNPS1_HUMANBioGRID, IntAct17353931 31617661 details
HTRA2_HUMANTNR14_HUMANIntAct17353931 details
HTRA2_HUMANARMC8_HUMANBioGRID, IntAct27173435 29911972 31617661 unassigned1312 details
HTRA2_HUMANMKLN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HTRA2_HUMANMAEA_HUMANBioGRID, IntAct27173435 unassigned1312 details
HTRA2_HUMANRBP10_HUMANBioGRID, IntAct27173435 unassigned1312 details
HTRA2_HUMANWDR26_HUMANBioGRID, IntAct27173435 unassigned1312 details
HTRA2_HUMANPRKN_HUMANBioGRID19631192 details
HTRA2_HUMANHAX1_HUMANBioGRID17906618 31617661 details
HTRA2_HUMANPINK1_HUMANBioGRID17906618 details
HTRA2_HUMANTNR5_HUMANBioGRID20614026 details
HTRA2_HUMANTERA_HUMANBioGRID26389662 details
HTRA2_HUMANCASP2_HUMANBioGRID29875129 details
HTRA2_HUMANTNR1A_HUMANBioGRID30420664 details
HTRA2_HUMANCASA1_HUMANHPRD10971580 details
HTRA2_HUMANA4_HUMANHPRD15036614 details
HTRA2_HUMANPEA15_HUMANHPRD15328349 details