Entity Details

Primary name AMFR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKV5
EntryNameAMFR_HUMAN
FullNameE3 ubiquitin-protein ligase AMFR
TaxID9606
Evidenceevidence at protein level
Length643
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesAMFR

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0007568 aging
GO:0007611 learning or memory
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030674 protein-macromolecule adaptor activity
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032092 positive regulation of protein binding
GO:0032991 protein-containing complex
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0036513 Derlin-1 retrotranslocation complex
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043130 ubiquitin binding
GO:0044322 endoplasmic reticulum quality control compartment
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0051087 chaperone binding
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904288 BAT3 complex binding
GO:1904380 endoplasmic reticulum mannose trimming
GO:1990381 ubiquitin-specific protease binding
GO:2000638 regulation of SREBP signaling pathway

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003892 Ubiquitin system component CUEDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR040675 E3 ubiquitin-protein ligase AMFR, Ube2g2-binding regionDomainDomain

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
AMFR_HUMANUB2G2_HUMANBioGRID, DIP, HPRD, IntAct, MINT11724934 16407162 17310145 17353931 17681147 18216283 19223579 21636303 22119785 23223569 23942235 24366945 24424410 24496447 25409783 28434917 28884161 32333192 32614325 details
AMFR_HUMANTERA_HUMANBioGRID, DIP, HPRD, IntAct, UniProt15331598 16186510 16275660 16407162 16987818 17311810 17681147 17872946 18835813 19828134 20126661 21343306 21636303 21914798 22119785 22328510 23333620 23383273 24100225 26424800 26712280 27387505 28301499 29599191 details
AMFR_HUMANUB2D1_HUMANBioGRID, IntAct19549727 19690564 24810856 details
AMFR_HUMANUB2D2_HUMANBioGRID, HPRD, IntAct11724934 19549727 19690564 29643511 31061093 details
AMFR_HUMANUB2D3_HUMANBioGRID, IntAct19549727 19690564 details
AMFR_HUMANUB2D4_HUMANBioGRID, IntAct19549727 19690564 details
AMFR_HUMANUBE2N_HUMANBioGRID, IntAct19549727 19690564 details
AMFR_HUMANUBE2T_HUMANBioGRID, IntAct19690564 details
AMFR_HUMANUBE2W_HUMANBioGRID, IntAct19549727 19690564 details
AMFR_HUMANDPYL1_HUMANBioGRID, MINT21900206 details
AMFR_HUMANTM1L1_HUMANBioGRID, MINT21900206 details
AMFR_HUMANAMFR_HUMANBioGRID, DIP, MINT11724934 17310145 19223579 23942235 24810856 details
AMFR_HUMANHERP1_HUMANBioGRID, DIP17310145 19223579 21636303 21965653 24366945 24496447 25409783 26424800 details
AMFR_HUMANDERL2_HUMANBioGRID, IntAct18216283 21832065 22119785 23867461 26424800 details
AMFR_HUMANCP3A4_HUMANBioGRID19103148 21209460 22101235 25451919 details
AMFR_HUMANDERL1_HUMANBioGRID16186510 17872946 18216283 21832065 32614325 details
AMFR_HUMANUFD1_HUMANBioGRID17681147 32614325 details
AMFR_HUMANUBC_HUMANBioGRID11724934 12847084 15331598 16868077 18216283 19661182 20126661 21343306 23123110 23246001 25409783 31699778 details
AMFR_HUMANIMB1_HUMANBioGRID21832065 details
AMFR_HUMANSYVN1_HUMANBioGRID19828134 21832065 26424800 details
AMFR_HUMANHD_HUMANBioGRID20126661 details
AMFR_HUMANUB2G1_HUMANBioGRID12847084 19560420 19661182 21209460 22101235 25451919 31061093 details
AMFR_HUMANSODC_HUMANBioGRID19661182 details
AMFR_HUMANCP2E1_HUMANBioGRID21209460 details
AMFR_HUMANBAG6_HUMANBioGRID21636303 23246001 24424410 26424800 27387505 32614325 details
AMFR_HUMANUBL4A_HUMANBioGRID21636303 24424410 details
AMFR_HUMANMDC1_HUMANBioGRID22990118 details
AMFR_HUMANG6PI_HUMANBioGRID, HPRD16563432 24810856 details
AMFR_HUMANDYR_HUMANBioGRID24810856 details
AMFR_HUMANTRI25_HUMANBioGRID24810856 details
AMFR_HUMANUBE2K_HUMANBioGRID16868077 details
AMFR_HUMANUBP13_HUMANBioGRID24424410 details
AMFR_HUMANMGRN1_HUMANBioGRID26743086 30230921 details
AMFR_HUMANDUS1_HUMANBioGRID31061093 details
AMFR_HUMANFAF2_HUMANBioGRID, IntAct18775313 18835813 21636303 22119785 23665563 26424800 27387505 32614325 details
AMFR_HUMANDGAT2_HUMANBioGRID, MINT24820123 details
AMFR_HUMANERLN1_HUMANBioGRID, IntAct, UniProt21343306 22119785 32614325 details
AMFR_HUMANERLN2_HUMANBioGRID, IntAct, UniProt17502376 21343306 22119785 24217618 details
AMFR_HUMANINSI1_HUMANBioGRID, UniProt16168377 17043353 19815544 21343306 22143767 30733434 details
AMFR_HUMANTMUB1_HUMANBioGRID, IntAct, UniProt21343306 22119785 details
AMFR_HUMANHMDH_HUMANBioGRID, UniProt16168377 21343306 32614325 details
AMFR_HUMANCD3D_HUMANBioGRID, DIP16407162 17872946 details
AMFR_HUMANUBAC2_HUMANBioGRID, IntAct22119785 26424800 31073040 32614325 details
AMFR_HUMANCFTR_HUMANBioGRID18216283 19828134 26618866 details
AMFR_HUMANDERL3_HUMANBioGRID18216283 details
AMFR_HUMANRNF5_HUMANBioGRID18216283 details
AMFR_HUMANCH60_HUMANBioGRID17681147 details
AMFR_HUMANRL5_HUMANBioGRID17681147 details
AMFR_HUMANSVIP_HUMANBioGRID17872946 details
AMFR_HUMANSELS_HUMANBioGRID17872946 21832065 details
AMFR_HUMANPDIA2_HUMANBioGRID19864457 details
AMFR_HUMANINSI2_HUMANBioGRID19815544 30733434 details
AMFR_HUMANATX3_HUMANBioGRID19661182 details
AMFR_HUMANBIP_HUMANBioGRID21343306 25301734 26119938 details
AMFR_HUMANITPR1_HUMANBioGRID17502376 details
AMFR_HUMANCD82_HUMANBioGRID18037895 details
AMFR_HUMANSARAF_HUMANBioGRID18502753 details
AMFR_HUMANUBXN4_HUMANBioGRID16968747 details
AMFR_HUMANGET4_HUMANBioGRID21636303 24424410 details
AMFR_HUMANNPL4_HUMANBioGRID21636303 32614325 details
AMFR_HUMANAUP1_HUMANBioGRID23223569 32614325 details
AMFR_HUMANADRB2_HUMANBioGRID23798571 details
AMFR_HUMANOTU1_HUMANBioGRID24068323 details
AMFR_HUMANMAVS_HUMANBioGRID24285545 details
AMFR_HUMANPMP22_HUMANBioGRID25385046 details
AMFR_HUMANSE1L1_HUMANBioGRID26424800 details
AMFR_HUMANOS9_HUMANBioGRID26424800 27387505 details
AMFR_HUMANCIDEC_HUMANBioGRID28656280 details
AMFR_HUMANAPRIO_HUMANBioGRID28759037 details
AMFR_HUMANPRIO_HUMANBioGRID28759037 details
AMFR_HUMANHS71L_HUMANBioGRID28759037 details
AMFR_HUMANSOAT2_HUMANBioGRID28604676 details
AMFR_HUMANLNP_HUMANBioGRID27387505 details
AMFR_HUMANWDR20_HUMANBioGRID29655804 details
AMFR_HUMANCALM1_HUMANBioGRID30230921 details
AMFR_HUMANCALM2_HUMANBioGRID30230921 details
AMFR_HUMANCALM3_HUMANBioGRID30230921 details
AMFR_HUMANUBP34_HUMANBioGRID30585151 details
AMFR_HUMANLMBRL_HUMANBioGRID31073040 details
AMFR_HUMANCTNB1_HUMANBioGRID31073040 details
AMFR_HUMANPINK1_HUMANBioGRID31300519 details
AMFR_HUMANERD23_HUMANBioGRID31949145 details
AMFR_HUMANATLA1_HUMANBioGRID32916628 details