Entity Details

Primary name VPS4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UN37
EntryNameVPS4A_HUMAN
FullNameVacuolar protein sorting-associated protein 4A
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesVPS4A

GO terms

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GOName
GO:0000916 actomyosin contractile ring contraction
GO:0000922 spindle pole
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005774 vacuolar membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006622 protein targeting to lysosome
GO:0006900 vesicle budding from membrane
GO:0006997 nucleus organization
GO:0006998 nuclear envelope organization
GO:0007033 vacuole organization
GO:0007080 mitotic metaphase plate congression
GO:0007084 mitotic nuclear membrane reassembly
GO:0008022 protein C-terminus binding
GO:0009838 abscission
GO:0010008 endosome membrane
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016887 ATP hydrolysis activity
GO:0019058 viral life cycle
GO:0019076 viral release from host cell
GO:0019904 protein domain specific binding
GO:0030496 midbody
GO:0031468 nuclear membrane reassembly
GO:0031902 late endosome membrane
GO:0032367 intracellular cholesterol transport
GO:0032466 negative regulation of cytokinesis
GO:0032880 regulation of protein localization
GO:0034058 endosomal vesicle fusion
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044877 protein-containing complex binding
GO:0044878 mitotic cytokinesis checkpoint signaling
GO:0048471 perinuclear region of cytoplasm
GO:0051301 cell division
GO:0061640 cytoskeleton-dependent cytokinesis
GO:0061738 late endosomal microautophagy
GO:0061952 midbody abscission
GO:0070062 extracellular exosome
GO:0072319 vesicle uncoating
GO:0090543 Flemming body
GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO:1902188 positive regulation of viral release from host cell
GO:1903076 regulation of protein localization to plasma membrane
GO:1903543 positive regulation of exosomal secretion
GO:1903774 positive regulation of viral budding via host ESCRT complex
GO:1903902 positive regulation of viral life cycle
GO:1904896 ESCRT complex disassembly
GO:1904903 ESCRT III complex disassembly

Subcellular Location

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Subcellular Location
Late endosome membrane
Midbody

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR007330 MIT domainDomainDomain
IPR015415 Vps4 oligomerisation, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031255 Vacuolar protein sorting-associated protein 4FamilyFamily
IPR036181 MIT domain superfamilyFamilyHomologous superfamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
VPS4A_HUMANCHM1A_HUMANBioGRID, DIP, IntAct11559748 14505570 16730941 17928862 details
VPS4A_HUMANCHM2A_HUMANBioGRID, HPRD, IntAct14505570 16730941 details
VPS4A_HUMANCHM4A_HUMANBioGRID, HPRD, IntAct12860994 14505569 14505570 16730941 details
VPS4A_HUMANCHM4B_HUMANBioGRID, HPRD, IntAct12860994 16730941 details
VPS4A_HUMANCHM1B_HUMANBioGRID, DIP, HPRD, IntAct11559748 14505570 16730941 17928862 details
VPS4A_HUMANVPS4A_HUMANBioGRID, HPRD, IntAct16730941 details
VPS4A_HUMANCLIC3_HUMANBioGRID, IntAct32296183 details
VPS4A_HUMANVPS4B_HUMANBioGRID, HPRD, IntAct11563910 12594041 26186194 28514442 details
VPS4A_HUMANCHM2B_HUMANDIP17928862 details
VPS4A_HUMANCHM4C_HUMANBioGRID, DIP, HPRD14505570 24814515 details
VPS4A_HUMANNPC1_HUMANBioGRID16757520 details
VPS4A_HUMANOGT1_HUMANBioGRID32994395 details
VPS4A_HUMANRND2_HUMANHPRD11931639 details
VPS4A_HUMANTBA1A_HUMANMINT17853893 details
VPS4A_HUMANPDC6I_HUMANMINT17853893 details
VPS4A_HUMANNFKB1_HUMANIntAct20195357 details
VPS4A_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
VPS4A_HUMANVTA1_HUMANBioGRID, IntAct20164219 26186194 28514442 details
VPS4A_HUMANANCHR_HUMANBioGRID, DIP, IntAct24814515 26186194 28514442 details
VPS4A_HUMANCHMP3_HUMANBioGRID, DIP17146056 21543490 details
VPS4A_HUMANHGS_HUMANBioGRID14602072 details
VPS4A_HUMANCHMP5_HUMANBioGRID21543490 details
VPS4A_HUMANKCND3_HUMANBioGRID17725712 details
VPS4A_HUMANKMT2E_HUMANBioGRID26678539 details
VPS4A_HUMANSH3K1_HUMANBioGRID25005938 details