Entity Details

Primary name SIK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2K2
EntryNameSIK3_HUMAN
FullNameSerine/threonine-protein kinase SIK3
TaxID9606
Evidenceevidence at protein level
Length1321
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesSIK3

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
GO:0050321 tau-protein kinase activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904263 positive regulation of TORC1 signaling
GO:1904515 positive regulation of TORC2 signaling

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034672 Salt-Inducible kinase, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618162 OMIMSpondyloepimetaphyseal dysplasia, Krakow type (SEMDK)An autosomal recessive skeletal disorder characterized by severe spondyloepimetaphyseal dysplasia, rhizomelia, mesomelia with significant anterior bowing of all limbs, severe immunodeficiency, and developmental delay. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule