Entity Details

Primary name ACSL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60488
EntryNameACSL4_HUMAN
FullNameLong-chain-fatty-acid--CoA ligase 4
TaxID9606
Evidenceevidence at protein level
Length711
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesACSL4

GO terms

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GOName
GO:0001676 long-chain fatty acid metabolic process
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007584 response to nutrient
GO:0008610 lipid biosynthetic process
GO:0015908 fatty acid transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019432 triglyceride biosynthetic process
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0031957 very long-chain fatty acid-CoA ligase activity
GO:0032024 positive regulation of insulin secretion
GO:0032307 negative regulation of prostaglandin secretion
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0043025 neuronal cell body
GO:0044233 mitochondria-associated endoplasmic reticulum membrane
GO:0047676 arachidonate-CoA ligase activity
GO:0060136 embryonic process involved in female pregnancy
GO:0060996 dendritic spine development
GO:0070062 extracellular exosome
GO:0070672 response to interleukin-15

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion outer membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR000873 AMP-dependent synthetase/ligaseDomainDomain
IPR020845 AMP-binding, conserved siteSiteConserved site
IPR042099 ANL, N-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00159 IcosapentDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule