Entity Details

Primary name ROCK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75116
EntryNameROCK2_HUMAN
FullNameRho-associated protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length1388
SequenceStatuscomplete
DateCreated2004-05-24
DateModified2021-06-02

Ontological Relatives

GenesROCK2

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0002931 response to ischemia
GO:0003180 aortic valve morphogenesis
GO:0003723 RNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006939 smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007266 Rho protein signal transduction
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010825 positive regulation of centrosome duplication
GO:0016525 negative regulation of angiogenesis
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0030866 cortical actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031267 small GTPase binding
GO:0031644 regulation of nervous system process
GO:0032723 positive regulation of connective tissue growth factor production
GO:0032956 regulation of actin cytoskeleton organization
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0039694 viral RNA genome replication
GO:0042752 regulation of circadian rhythm
GO:0043410 positive regulation of MAPK cascade
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045616 regulation of keratinocyte differentiation
GO:0046872 metal ion binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048156 tau protein binding
GO:0048511 rhythmic process
GO:0048598 embryonic morphogenesis
GO:0050321 tau-protein kinase activity
GO:0051246 regulation of protein metabolic process
GO:0051298 centrosome duplication
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0061157 mRNA destabilization
GO:0070168 negative regulation of biomineral tissue development
GO:0071394 cellular response to testosterone stimulus
GO:0071559 response to transforming growth factor beta
GO:0072518 Rho-dependent protein serine/threonine kinase activity
GO:0072659 protein localization to plasma membrane
GO:0090271 positive regulation of fibroblast growth factor production
GO:0097746 blood vessel diameter maintenance
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110061 regulation of angiotensin-activated signaling pathway
GO:0150033 negative regulation of protein localization to lysosome
GO:1900037 regulation of cellular response to hypoxia
GO:1901888 regulation of cell junction assembly
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1905145 cellular response to acetylcholine
GO:1905205 positive regulation of connective tissue replacement
GO:1990776 response to angiotensin
GO:2000114 regulation of establishment of cell polarity
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011072 HR1 rho-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015008 ROCK, Rho binding domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020684 Rho-associated protein kinase 1/2FamilyFamily
IPR037311 Rho-associated protein kinase 2, HR1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08162 FasudilDrugbanksmall molecule
DB08756 Y-27632Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB13165 RipasudilDrugbanksmall molecule
DB13931 NetarsudilDrugbanksmall molecule