Entity Details

Primary name LRP6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75581
EntryNameLRP6_HUMAN
FullNameLow-density lipoprotein receptor-related protein 6
TaxID9606
Evidenceevidence at protein level
Length1613
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesLRP6

GO terms

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GOName
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0003344 pericardium morphogenesis
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0009880 embryonic pattern specification
GO:0009986 cell surface
GO:0014029 neural crest formation
GO:0014033 neural crest cell differentiation
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016055 Wnt signaling pathway
GO:0017147 Wnt-protein binding
GO:0019210 kinase inhibitor activity
GO:0019534 toxin transmembrane transporter activity
GO:0021587 cerebellum morphogenesis
GO:0021794 thalamus development
GO:0021987 cerebral cortex development
GO:0030278 regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0034185 apolipoprotein binding
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035261 external genitalia morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0043025 neuronal cell body
GO:0043434 response to peptide hormone
GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060021 roof of mouth development
GO:0060026 convergent extension
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060535 trachea cartilage morphogenesis
GO:0071397 cellular response to cholesterol
GO:0071542 dopaminergic neuron differentiation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090009 primitive streak formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090245 axis elongation involved in somitogenesis
GO:0098609 cell-cell adhesion
GO:1904886 beta-catenin destruction complex disassembly
GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990851 Wnt-Frizzled-LRP5/6 complex
GO:1990909 Wnt signalosome

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum
Membrane raft

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000742 EGF-like domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR017049 Low density lipoprotein receptor-related protein 5/6FamilyFamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
LRP6_HUMANAXIN1_HUMANBioGRID, DIP, HPRD, IntAct12897152 16890161 19107203 20128690 22682247 23892894 23959799 24976009 28966723 details
LRP6_HUMANWNT3A_HUMANBioGRID, DIP, HPRD, IntAct12897152 14739301 19910923 21944579 22726442 details
LRP6_HUMANLRRK2_HUMANBioGRID, IntAct22899650 27013965 details
LRP6_HUMANAT132_HUMANBioGRID, IntAct22645275 details
LRP6_HUMANGSK3A_HUMANbhf-ucl, BioGRID, UniProt16365045 30824926 details
LRP6_HUMANGSK3B_HUMANbhf-ucl, BioGRID, HPRD16365045 16890161 19107203 details
LRP6_HUMANDKK1_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct11357136 11448771 15035989 21944579 21984209 26186194 27322059 28514442 details
LRP6_HUMANSOST_HUMANbhf-ucl, BioGRID, DIP, IntAct, UniProt15908424 21471202 21944579 28514442 details
LRP6_HUMANLRP6_HUMANbhf-ucl, BioGRID, DIP, HPRD12897152 21984209 28966723 details
LRP6_HUMANCKLF_HUMANBioGRID, IntAct32296183 details
LRP6_HUMANDKK2_HUMANDIP, HPRD11357136 11742004 21944579 details
LRP6_HUMANAPOB_HUMANBioGRID18948618 details
LRP6_HUMANFZD8_HUMANBioGRID, HPRD11029007 11448771 15908424 details
LRP6_HUMANWNT1_HUMANBioGRID, HPRD11029007 11448771 details
LRP6_HUMANPEDF_HUMANBioGRID21576363 details
LRP6_HUMANMK_HUMANBioGRID12573468 details
LRP6_HUMANANTR1_HUMANHPRD, IntAct16564009 details
LRP6_HUMANANTR2_HUMANHPRD, IntAct16564009 details
LRP6_HUMANAMMR1_HUMANMINT21304492 details
LRP6_HUMANDAB2_HUMANMINT22491013 details
LRP6_HUMANCAPR2_HUMANbhf-ucl, BioGRID18762581 details
LRP6_HUMANCAV1_HUMANbhf-ucl, BioGRID16890161 28966723 34079125 details
LRP6_HUMANCTNB1_HUMANbhf-ucl, BioGRID16890161 31262711 details
LRP6_HUMANEEA1_HUMANbhf-ucl16890161 details
LRP6_HUMANRB11A_HUMANbhf-ucl16890161 details
LRP6_HUMANBAMBI_HUMANbhf-ucl18838381 details
LRP6_HUMANIBP4_HUMANDIP18528331 details
LRP6_HUMANPGFRB_HUMANDIP21245321 details
LRP6_HUMANZNRF3_HUMANBioGRID, DIP22575959 details
LRP6_HUMANRIPK4_HUMANDIP23371553 details
LRP6_HUMANNPC1_HUMANBioGRID18948618 details
LRP6_HUMANWNT5A_HUMANBioGRID19910923 details
LRP6_HUMANFZD5_HUMANBioGRID, HPRD12121999 12857724 details
LRP6_HUMANLGR4_HUMANBioGRID24639526 details
LRP6_HUMANIQGA1_HUMANBioGRID24639526 details
LRP6_HUMANEPN1_HUMANBioGRID25871009 details
LRP6_HUMANLRP5_HUMANBioGRID28966723 details
LRP6_HUMANITCH_HUMANBioGRID28966723 details
LRP6_HUMANLMBRL_HUMANBioGRID31073040 details
LRP6_HUMANTRAF6_HUMANBioGRID31262711 details
LRP6_HUMANTLRN1_HUMANHPRD16989816 details