Entity Details

Primary name RPGF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95398
EntryNameRPGF3_HUMAN
FullNameRap guanine nucleotide exchange factor 3
TaxID9606
Evidenceevidence at protein level
Length923
SequenceStatuscomplete
DateCreated2003-06-20
DateModified2021-06-02

Ontological Relatives

GenesRAPGEF3

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002250 adaptive immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0007165 signal transduction
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0019904 protein domain specific binding
GO:0019933 cAMP-mediated signaling
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030552 cAMP binding
GO:0032486 Rap protein signal transduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034242 negative regulation of syncytium formation by plasma membrane fusion
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0046827 positive regulation of protein export from nucleus
GO:0050796 regulation of insulin secretion
GO:0051496 positive regulation of stress fiber assembly
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0071320 cellular response to cAMP
GO:1901985 positive regulation of protein acetylation
GO:2000249 regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Endomembrane system

Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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