Entity Details

Primary name DDX58_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95786
EntryNameDDX58_HUMAN
FullNameAntiviral innate immune response receptor RIG-I
TaxID9606
Evidenceevidence at protein level
Length925
SequenceStatuscomplete
DateCreated2005-11-08
DateModified2021-06-02

Ontological Relatives

GenesDDX58

GO terms

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GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0002735 positive regulation of myeloid dendritic cell cytokine production
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0008270 zinc ion binding
GO:0009597 detection of virus
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0015629 actin cytoskeleton
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0016787 hydrolase activity
GO:0030334 regulation of cell migration
GO:0031625 ubiquitin protein ligase binding
GO:0032480 negative regulation of type I interferon production
GO:0032587 ruffle membrane
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034344 regulation of type III interferon production
GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus
GO:0039529 RIG-I signaling pathway
GO:0042802 identical protein binding
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051607 defense response to virus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0140374 antiviral innate immune response
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR021673 RIG-I-like receptor, C-terminal regulatory domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031964 Caspase recruitment domainDomainDomain
IPR038557 RIG-I-like receptor, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041204 RIG-I receptor, C-terminalDomainDomain
IPR042145 RIG-I, CARD domain repeat 2DomainDomain

Diseases

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Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
DDX58_HUMANMAVS_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, UniProt16127453 16153868 16177806 16585524 17190814 17709747 18200010 19164550 19193793 19454348 20007272 20071582 20080758 20406818 20434986 20554965 21102435 21292167 21844353 21903422 22022264 22114345 22301138 22623778 24478431 26061460 26494172 28594325 29053956 29263274 30193849 30267576 30558248 31433974 33372174 details
DDX58_HUMANUBC_HUMANBioGRID, MINT18636086 20403326 23264040 details
DDX58_HUMANTRI25_HUMANBioGRID, InnateDB, UniProt17392790 19484123 19675569 20071582 20406818 20818395 21292167 22114345 23264040 23950712 24478431 25172487 27122586 28148787 28594325 29357390 29563291 30193849 30342007 30902577 31176400 31600868 31710640 32513696 888800000216 details
DDX58_HUMANDDX58_HUMANBioGRID, DIP, InnateDB17190814 20581823 21102435 23264040 24590070 29563291 details
DDX58_HUMANZCCHV_HUMANInnateDB21102435 details
DDX58_HUMANWRIP1_HUMANBioGRID, IntAct21903422 29053956 details
DDX58_HUMANATG5_HUMANDIP17709747 details
DDX58_HUMANUBE2K_HUMANBioGRID17719635 32513696 details
DDX58_HUMANUB2D1_HUMANBioGRID17719635 details
DDX58_HUMANUB2D2_HUMANBioGRID17719635 details
DDX58_HUMANUB2D3_HUMANBioGRID17719635 details
DDX58_HUMANP52K_HUMANBioGRID21910972 details
DDX58_HUMANKPCA_HUMANBioGRID22114345 details
DDX58_HUMANKPCB_HUMANBioGRID22114345 details
DDX58_HUMANKPCG_HUMANBioGRID22114345 details
DDX58_HUMANRN135_HUMANBioGRID19017631 19484123 23950712 31006531 details
DDX58_HUMANUBP3_HUMANBioGRID24366338 details
DDX58_HUMANUBP15_HUMANBioGRID26061460 details
DDX58_HUMANRN122_HUMANBioGRID27506794 details
DDX58_HUMANTRI40_HUMANBioGRID29117565 details
DDX58_HUMANSNX5_HUMANBioGRID31806368 details
DDX58_HUMANCYLD_HUMANBioGRID, HPRD, MINT18636086 details
DDX58_HUMANDDX3X_HUMANUniProt20127681 details
DDX58_HUMANSTAT1_HUMANIntAct24360797 details
DDX58_HUMANPRKRA_HUMANBioGRID, DIP, UniProt23870315 28591694 details
DDX58_HUMANNOP53_HUMANBioGRID, IntAct27824081 details
DDX58_HUMANDHX58_HUMANBioGRID, DIP17190814 31237466 details
DDX58_HUMANRN125_HUMANBioGRID, DIP17460044 31827077 details
DDX58_HUMANSTING_HUMANBioGRID, DIP, IntAct18724357 22312431 details
DDX58_HUMANUBB_HUMANIntAct24622840 details
DDX58_HUMANIRF3_HUMANBioGRID16153868 18636086 details
DDX58_HUMANHOIL1_HUMANBioGRID21292167 32513696 details
DDX58_HUMANRNF31_HUMANBioGRID21292167 32513696 details
DDX58_HUMANISG15_HUMANBioGRID16009940 29288164 details
DDX58_HUMANTRI32_HUMANBioGRID22745133 details
DDX58_HUMANTSN6_HUMANBioGRID22908223 details
DDX58_HUMANSRC_HUMANBioGRID19419966 details
DDX58_HUMANMBP_HUMANBioGRID23264040 details
DDX58_HUMANUBP4_HUMANBioGRID23388719 details
DDX58_HUMANNLRC5_HUMANBioGRID20434986 details
DDX58_HUMANTBK1_HUMANBioGRID23950712 details
DDX58_HUMANIKKE_HUMANBioGRID23950712 details
DDX58_HUMANNEMO_HUMANBioGRID23950712 32513696 details
DDX58_HUMANUBP21_HUMANBioGRID24493797 details
DDX58_HUMANMEX3C_HUMANBioGRID24706898 details
DDX58_HUMANIFIT3_HUMANBioGRID21813773 details
DDX58_HUMANIRGM_HUMANBioGRID25891078 details
DDX58_HUMANUBD_HUMANBioGRID26996158 31433974 details
DDX58_HUMANHDAC6_HUMANBioGRID26746851 details
DDX58_HUMANTRI14_HUMANBioGRID29053956 details
DDX58_HUMANPPP6_HUMANBioGRID29053956 details
DDX58_HUMANFBXW7_HUMANBioGRID28287082 details
DDX58_HUMANPTN11_HUMANBioGRID28287082 details
DDX58_HUMANCBL_HUMANBioGRID28287082 details
DDX58_HUMANPPIA_HUMANBioGRID28594325 32513696 details
DDX58_HUMANWDR82_HUMANBioGRID26519536 details
DDX58_HUMANZCHC3_HUMANBioGRID30193849 details
DDX58_HUMANCHIP_HUMANBioGRID29593341 details
DDX58_HUMANKMT2E_HUMANBioGRID29593341 details
DDX58_HUMANFKBP8_HUMANBioGRID30267576 details
DDX58_HUMANLRC25_HUMANBioGRID29288164 31068071 details
DDX58_HUMANSQSTM_HUMANBioGRID29288164 31068071 details
DDX58_HUMANUBP14_HUMANBioGRID30466171 details
DDX58_HUMANLRC59_HUMANBioGRID31068071 details
DDX58_HUMANRNF34_HUMANBioGRID31304625 details
DDX58_HUMANZN598_HUMANBioGRID31433974 32513696 details
DDX58_HUMANMEX3A_HUMANBioGRID32019099 details
DDX58_HUMANG3BP1_HUMANBioGRID31827077 details
DDX58_HUMANMARH5_HUMANBioGRID31881323 details