Entity Details

Primary name KNG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01042
EntryNameKNG1_HUMAN
FullNameKininogen-1
TaxID9606
Evidenceevidence at protein level
Length644
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesKNG1

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007162 negative regulation of cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007597 blood coagulation, intrinsic pathway
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0010951 negative regulation of endopeptidase activity
GO:0030195 negative regulation of blood coagulation
GO:0031093 platelet alpha granule lumen
GO:0031640 killing of cells of other organism
GO:0042311 vasodilation
GO:0043065 positive regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045861 negative regulation of proteolysis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000010 Cystatin domainDomainDomain
IPR002395 HMW kininogenFamilyFamily
IPR018073 Proteinase inhibitor I25, cystatin, conserved siteSiteConserved site
IPR027358 Kininogen-type cystatin domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
KNG1_HUMANC1QBP_HUMANUniProt8710908 details
KNG1_HUMANFA20C_HUMANIntAct22582013 details
KNG1_HUMANUPAR_HUMANBioGRID, HPRD14764580 details
KNG1_HUMANKLKB1_HUMANBioGRID, HPRD10464316 291905 500690 7686159 7944388 details
KNG1_HUMANFA11_HUMANBioGRID, HPRD1652157 291905 3936495 details
KNG1_HUMANK2C1_HUMANBioGRID, HPRD10066772 details
KNG1_HUMANVTNC_HUMANBioGRID, HPRD10887113 details
KNG1_HUMANFRIL_HUMANBioGRID, HPRD12071855 details
KNG1_HUMANPLMN_HUMANBioGRID, HPRD9428707 details
KNG1_HUMANELNE_HUMANBioGRID, HPRD12887060 details
KNG1_HUMANITB2_HUMANBioGRID, HPRD10845911 details
KNG1_HUMANC1QR1_HUMANBioGRID, HPRD12213329 8710908 details
KNG1_HUMANECE1_HUMANBioGRID18039931 details
KNG1_HUMANMEP1A_HUMANBioGRID, HPRD11278902 details
KNG1_HUMANKLK1_HUMANBioGRID, HPRD12492488 3643793 7492318 9276160 details
KNG1_HUMANCAN1_HUMANBioGRID, HPRD, IntAct26186194 28514442 3038169 8253784 details
KNG1_HUMANTHRB_HUMANHPRD1652157 details
KNG1_HUMANTSP1_HUMANHPRD9459346 details
KNG1_HUMANKNG1_HUMANHPRD12071855 details
KNG1_HUMANGP1BA_HUMANHPRD9269768 details
KNG1_HUMANCATK_HUMANHPRD12492488 7492318 9276160 details
KNG1_HUMANHABP2_HUMANHPRD12452440 details
KNG1_HUMANCBPN_HUMANHPRD14687935 details
KNG1_HUMANRL3R2_HUMANHPRD14530218 details
KNG1_HUMANCAN2_HUMANHPRD3038169 details
KNG1_HUMANCATG_HUMANHPRD11920276 details
KNG1_HUMANCATS_HUMANHPRD8706894 details
KNG1_HUMANCATL1_HUMANHPRD11517935 details
KNG1_HUMANPPCE_HUMANHPRD12173 details
KNG1_HUMANA4_HUMANHPRD12090937 details
KNG1_HUMANANGT_HUMANHPRD11677365 details