Entity Details

Primary name INS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01308
EntryNameINS_HUMAN
FullNameInsulin
TaxID9606
Evidenceevidence at protein level
Length110
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesINS

GO terms

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GOName
GO:1990000 amyloid fibril formation
GO:0005159 insulin-like growth factor receptor binding
GO:0042177 negative regulation of protein catabolic process
GO:0042593 glucose homeostasis
GO:0045721 negative regulation of gluconeogenesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1990535 neuron projection maintenance
GO:0002674 negative regulation of acute inflammatory response
GO:0045922 negative regulation of fatty acid metabolic process
GO:1900182 positive regulation of protein localization to nucleus
GO:0005576 extracellular region
GO:0043410 positive regulation of MAPK cascade
GO:0045861 negative regulation of proteolysis
GO:0007267 cell-cell signaling
GO:0032270 positive regulation of cellular protein metabolic process
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0006521 regulation of cellular amino acid metabolic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0008284 positive regulation of cell population proliferation
GO:0042311 vasodilation
GO:0048167 regulation of synaptic plasticity
GO:0055089 fatty acid homeostasis
GO:0060267 positive regulation of respiratory burst
GO:0090336 positive regulation of brown fat cell differentiation
GO:0008286 insulin receptor signaling pathway
GO:0042060 wound healing
GO:0045840 positive regulation of mitotic nuclear division
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050890 cognition
GO:0050995 negative regulation of lipid catabolic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0006355 regulation of transcription, DNA-templated
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0046631 alpha-beta T cell activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034774 secretory granule lumen
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0030307 positive regulation of cell growth
GO:0031904 endosome lumen
GO:0032880 regulation of protein localization
GO:0030133 transport vesicle
GO:0031954 positive regulation of protein autophosphorylation
GO:0050709 negative regulation of protein secretion
GO:1902952 positive regulation of dendritic spine maintenance
GO:1903076 regulation of protein localization to plasma membrane
GO:0002020 protease binding
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0010628 positive regulation of gene expression
GO:0042802 identical protein binding
GO:0090277 positive regulation of peptide hormone secretion
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0045597 positive regulation of cell differentiation
GO:0001819 positive regulation of cytokine production
GO:0005158 insulin receptor binding
GO:0030335 positive regulation of cell migration
GO:1900273 positive regulation of long-term synaptic potentiation
GO:0032148 activation of protein kinase B activity
GO:0045818 negative regulation of glycogen catabolic process
GO:0050708 regulation of protein secretion
GO:0000139 Golgi membrane
GO:0022898 regulation of transmembrane transporter activity
GO:0038060 nitric oxide-cGMP-mediated signaling pathway
GO:2000252 negative regulation of feeding behavior
GO:0006006 glucose metabolic process
GO:0046326 positive regulation of glucose import
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0045821 positive regulation of glycolytic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR004825 InsulinFamilyFamily
IPR016179 Insulin-likeDomainDomain
IPR022352 Insulin familyFamilyFamily
IPR022353 Insulin, conserved siteSiteConserved site
IPR036438 Insulin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB01776 M-CresolDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
INS_HUMANINS_HUMANBioGRID, DIP, HPRD, MINT, UniProt10508408 12021212 17472440 20738396 22854022 23106816 23416304 23510797 32457219 8844841 details
INS_HUMANMK06_HUMANBioGRID, MINT21900206 details
INS_HUMANPGS2_HUMANmatrixdb24389353 details
INS_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
INS_HUMANATL4_HUMANBioGRID, IntAct32296183 details
INS_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
INS_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
INS_HUMANIDE_HUMANBioGRID, DIP, HPRD11145591 17051221 29273204 details
INS_HUMANINSR_HUMANDIP, HPRD23302862 2550426 29512653 details
INS_HUMANTXD17_HUMANBioGRID, HPRD14607844 details
INS_HUMANKMT2A_HUMANBioGRID14607844 details
INS_HUMANCCN3_HUMANBioGRID, HPRD10084601 details
INS_HUMANIBP7_HUMANBioGRID, HPRD9388210 details
INS_HUMANCRYAB_HUMANBioGRID17487982 details
INS_HUMANA4_HUMANBioGRID21832049 details
INS_HUMANHSPB1_HUMANBioGRID10383393 details
INS_HUMANITF2_HUMANBioGRID25416956 details
INS_HUMANRGS20_HUMANBioGRID25416956 details
INS_HUMANPTEN_HUMANBioGRID11439092 details
INS_HUMANHSP7C_HUMANBioGRID29764935 32457219 details
INS_HUMANHS71A_HUMANBioGRID29764935 details
INS_HUMANHS71B_HUMANBioGRID29764935 details
INS_HUMANKRA13_HUMANBioGRID32296183 details
INS_HUMANNT2NA_HUMANBioGRID32296183 details
INS_HUMANRB_HUMANBioGRID, HPRD10938588 7818556 details
INS_HUMANPRDX4_HUMANBioGRID32457219 details
INS_HUMANCATB_HUMANBioGRID, HPRD32457219 6351842 details
INS_HUMANBIP_HUMANBioGRID32457219 details
INS_HUMANMY18A_HUMANBioGRID32457219 details
INS_HUMANDJC10_HUMANBioGRID32457219 details
INS_HUMANENPL_HUMANBioGRID32457219 details
INS_HUMANLRP2_HUMANHPRD9773776 details
INS_HUMANDQB1_HUMANHPRD11376336 details
INS_HUMANSYTL4_HUMANHPRD10497219 details
INS_HUMANDQA2_HUMANHPRD11376336 details
INS_HUMANCBPE_HUMANHPRD10966857 7477119 details
INS_HUMANCATD_HUMANHPRD11779865 details
INS_HUMANCATE_HUMANHPRD195962 1959628 details
INS_HUMANHXK4_HUMANHPRD12101177 details
INS_HUMANIGF1R_HUMANHPRD1851182 details