Entity Details

Primary name PLF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02776
EntryNamePLF4_HUMAN
FullNamePlatelet factor 4
TaxID9606
Evidenceevidence at protein level
Length101
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPF4

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0020005 symbiont-containing vacuole membrane
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031093 platelet alpha granule lumen
GO:0031640 killing of cells of other organism
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042127 regulation of cell population proliferation
GO:0042832 defense response to protozoan
GO:0045236 CXCR chemokine receptor binding
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045651 positive regulation of macrophage differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048248 CXCR3 chemokine receptor binding
GO:0051873 killing by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001089 CXC chemokineFamilyFamily
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR018048 CXC chemokine, conserved siteSiteConserved site
IPR027222 Platelet factor 4FamilyFamily
IPR033899 CXC Chemokine domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00055 Drotrecogin alfaDrugbankbiotech
DB01109 HeparinDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
PLF4_HUMANTSG6_HUMANIntAct27044744 details
PLF4_HUMANCCL5_HUMANbhf-ucl, BioGRID, HPRD15459010 28381538 details
PLF4_HUMANCXL17_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCXL14_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANSDF1_HUMANbhf-ucl, BioGRID10233851 28381538 details
PLF4_HUMANCXL11_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCXL10_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCXCL9_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANIL8_HUMANbhf-ucl, BioGRID, HPRD12586630 15531763 28381538 details
PLF4_HUMANCXCL6_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANPLF4_HUMANbhf-ucl, BioGRID, HPRD28381538 7547867 7835432 8031770 details
PLF4_HUMANCXCL2_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANXCL1_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL28_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL26_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL25_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL21_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL20_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL17_HUMANbhf-ucl28381538 details
PLF4_HUMANCCL13_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL11_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCCL2_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANXCL2_HUMANbhf-ucl, BioGRID28381538 details
PLF4_HUMANCXCR3_HUMANBioGRID, HPRD12782716 details
PLF4_HUMANTRBM_HUMANBioGRID, HPRD9395524 details
PLF4_HUMANPROC_HUMANBioGRID, HPRD9395524 details
PLF4_HUMANLDLR_HUMANBioGRID, HPRD11986215 details
PLF4_HUMANCSPG2_HUMANBioGRID11083865 details
PLF4_HUMANAPOH_HUMANIntAct19805618 details
PLF4_HUMANSRGN_HUMANHPRD8613703 details
PLF4_HUMANFGF2_HUMANHPRD9558385 details
PLF4_HUMANSDC2_HUMANHPRD7524669 details