Entity Details

Primary name DPOLB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06746
EntryNameDPOLB_HUMAN
FullNameDNA polymerase beta
TaxID9606
Evidenceevidence at protein level
Length335
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesPOLB

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006286 base-excision repair, base-free sugar-phosphate removal
GO:0006287 base-excision repair, gap-filling
GO:0006288 base-excision repair, DNA ligation
GO:0006290 pyrimidine dimer repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007435 salivary gland morphogenesis
GO:0007568 aging
GO:0008017 microtubule binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016579 protein deubiquitination
GO:0016829 lyase activity
GO:0019899 enzyme binding
GO:0032991 protein-containing complex
GO:0045471 response to ethanol
GO:0046872 metal ion binding
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048872 homeostasis of number of cells
GO:0051402 neuron apoptotic process
GO:0055093 response to hyperoxia
GO:0071707 immunoglobulin heavy chain V-D-J recombination

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002008 DNA polymerase family X, beta-likeFamilyFamily
IPR002054 DNA-directed DNA polymerase XDomainDomain
IPR003583 Helix-hairpin-helix DNA-binding motif, class 1DomainDomain
IPR010996 DNA polymerase beta-like, N-terminal domainDomainDomain
IPR018944 DNA polymerase lambda, fingers domainDomainDomain
IPR019843 DNA polymerase family X, binding siteSiteBinding site
IPR022312 DNA polymerase family XFamilyFamily
IPR027421 DNA polymerase lambda lyase domain superfamilyFamilyHomologous superfamily
IPR028207 DNA polymerase beta, palm domainDomainDomain
IPR029398 DNA polymerase beta, thumb domainDomainDomain
IPR037160 DNA polymerase, thumb domain superfamilyFamilyHomologous superfamily
IPR043519 Nucleotidyltransferase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00987 CytarabineDrugbanksmall molecule
DB01592 IronDrugbanksmall molecule
DB03222 dATPDrugbanksmall molecule
DB07479 (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOLDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule