Entity Details

Primary name CALCA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06881
EntryNameCALCA_HUMAN
FullNameCalcitonin gene-related peptide 1
TaxID9606
Evidenceevidence at protein level
Length128
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesCALCA

GO terms

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GOName
GO:0001878 response to yeast
GO:0001935 endothelial cell proliferation
GO:0001944 vasculature development
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0002031 G protein-coupled receptor internalization
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007159 leukocyte cell-cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0031623 receptor internalization
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032757 positive regulation of interleukin-8 production
GO:0042311 vasodilation
GO:0043542 endothelial cell migration
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045651 positive regulation of macrophage differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045776 negative regulation of blood pressure
GO:0045779 negative regulation of bone resorption
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0097647 amylin receptor signaling pathway
GO:1990408 calcitonin gene-related peptide receptor signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001693 Calcitonin peptide-likeDomainDomain
IPR015476 Calcitonin gene-related peptideFamilyFamily
IPR018360 Calcitonin, conserved siteSiteConserved site
IPR021116 Calcitonin/adrenomedullinFamilyFamily
IPR021117 Calcitonin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04869 OlcegepantDrugbanksmall molecule
DB12228 TelcagepantDrugbanksmall molecule
DB14040 EptinezumabDrugbankbiotech
DB14041 FremanezumabDrugbankbiotech
DB14042 GalcanezumabDrugbankbiotech

Interactions

5 interactions