Entity Details

Primary name HCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08631
EntryNameHCK_HUMAN
FullNameTyrosine-protein kinase HCK
TaxID9606
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesHCK

GO terms

Show/Hide Table
GOName
GO:0001784 phosphotyrosine residue binding
GO:0002522 leukocyte migration involved in immune response
GO:0002758 innate immune response-activating signal transduction
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007498 mesoderm development
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030133 transport vesicle
GO:0030154 cell differentiation
GO:0030838 positive regulation of actin filament polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043299 leukocyte degranulation
GO:0045087 innate immune response
GO:0045728 respiratory burst after phagocytosis
GO:0046777 protein autophosphorylation
GO:0050690 regulation of defense response to virus by virus
GO:0050727 regulation of inflammatory response
GO:0050764 regulation of phagocytosis
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071801 regulation of podosome assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Lysosome
Membrane
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035851 Tyrosine-protein kinase HCK, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB01962 PhosphonotyrosineDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

141 interactions

InteractorPartnerSourcesPublicationsLink
HCK_HUMANWIPF1_HUMANBioGRID, HPRD, MINT12029088 details
HCK_HUMANWASP_HUMANBioGRID, HPRD, mbinfo, MINT10068673 12029088 12235133 12769846 19234535 9742969 details
HCK_HUMANELMO1_HUMANBioGRID, HPRD, MINT12029088 details
HCK_HUMANSOS1_HUMANHPRD, IntAct, MINT12029088 17141806 23397142 details
HCK_HUMANASAP1_HUMANHPRD, MINT12029088 16636290 details
HCK_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct, MINT11278465 12029088 17141806 22641034 22745667 details
HCK_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
HCK_HUMANPAK2_HUMANBioGRID, HPRD, MINT16374509 details
HCK_HUMANADA15_HUMANBioGRID, HPRD, MINT, UniProt11741929 16374509 25825872 details
HCK_HUMANMED28_HUMANBioGRID, MINT16964398 details
HCK_HUMANADA22_HUMANMINT17141806 details
HCK_HUMANSPR2A_HUMANBioGRID, MINT18155796 details
HCK_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
HCK_HUMANABI1_HUMANMINT20598684 details
HCK_HUMANM4K5_HUMANBioGRID, IntAct20936779 details
HCK_HUMANPDC6I_HUMANMINT20670214 22641034 details
HCK_HUMANFHL2_HUMANBioGRID, MINT21516116 details
HCK_HUMANABL2_HUMANBioGRID, HPRD, IntAct12748290 21988832 details
HCK_HUMANWNT2_HUMANBioGRID, IntAct21988832 details
HCK_HUMANEGFR_HUMANBioGRID, IntAct23397142 24658140 25402006 31980649 details
HCK_HUMANLOX5_HUMANMINT24860872 details
HCK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
HCK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
HCK_HUMANKIT_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
HCK_HUMANMET_HUMANBioGRID, IntAct24728074 details
HCK_HUMANP55G_HUMANBioGRID, IntAct25814554 details
HCK_HUMANNGEF_HUMANBioGRID, IntAct25814554 details
HCK_HUMANFAK1_HUMANBioGRID, IntAct25814554 details
HCK_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
HCK_HUMANLTMD1_HUMANBioGRID, IntAct25814554 details
HCK_HUMANGRB14_HUMANBioGRID, IntAct25814554 details
HCK_HUMANFRS3_HUMANBioGRID, IntAct25814554 details
HCK_HUMANCBL_HUMANBioGRID, HPRD, IntAct10092522 10799548 11239464 11896602 11994282 22974441 8995358 9890970 details
HCK_HUMANKR109_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANMTUS2_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANK1C40_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANNT2NA_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANGOPC_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANKR108_HUMANBioGRID, IntAct32296183 details
HCK_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
HCK_HUMANNT2NC_HUMANBioGRID, IntAct25416956 32296183 details
HCK_HUMANCC88B_HUMANBioGRID, IntAct32296183 details
HCK_HUMANCTG1B_HUMANBioGRID, IntAct32296183 details
HCK_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
HCK_HUMANTRI27_HUMANBioGRID, IntAct32296183 details
HCK_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKRT36_HUMANBioGRID, IntAct32296183 details
HCK_HUMANTOX2_HUMANBioGRID, IntAct32296183 details
HCK_HUMANFHL5_HUMANBioGRID, IntAct32296183 details
HCK_HUMANBPIA1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
HCK_HUMANNEUFC_HUMANBioGRID, IntAct32296183 details
HCK_HUMANAP4AT_HUMANBioGRID, IntAct32296183 details
HCK_HUMANSH2B2_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKRT35_HUMANBioGRID, IntAct32296183 details
HCK_HUMANPNMA1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANTRIP6_HUMANBioGRID, IntAct32296183 details
HCK_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKR107_HUMANBioGRID, IntAct32296183 details
HCK_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
HCK_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANPKHG4_HUMANBioGRID, IntAct32296183 details
HCK_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
HCK_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
HCK_HUMANZSCA4_HUMANBioGRID, IntAct32296183 details
HCK_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
HCK_HUMANMK_HUMANBioGRID, IntAct32296183 details
HCK_HUMANGPVI_HUMANDIP19940238 details
HCK_HUMANADA12_HUMANUniProt25825872 details
HCK_HUMANADA19_HUMANUniProt25825872 details
HCK_HUMANNAL12_HUMANI2D32226298 details
HCK_HUMANWFS1_HUMANIntAct32814053 details
HCK_HUMANRPGF1_HUMANBioGRID, HPRD10318861 12734187 14551197 details
HCK_HUMANU119A_HUMANBioGRID, HPRD12496276 details
HCK_HUMANDOK1_HUMANBioGRID, HPRD11071635 details
HCK_HUMANBCAR1_HUMANBioGRID, HPRD9020138 details
HCK_HUMANSKAP2_HUMANBioGRID, HPRD29568343 9837776 details
HCK_HUMANBTK_HUMANBioGRID, HPRD8058772 details
HCK_HUMANCSF3R_HUMANBioGRID, HPRD9790917 details
HCK_HUMANRL10_HUMANBioGRID12138090 details
HCK_HUMANRASA3_HUMANBioGRID, HPRD7782336 details
HCK_HUMANRASA1_HUMANBioGRID, HPRD7782336 details
HCK_HUMANCBP_HUMANBioGRID22364282 details
HCK_HUMANACK1_HUMANBioGRID14506255 21309750 details
HCK_HUMANA4_HUMANBioGRID21832049 details
HCK_HUMANSTAT3_HUMANBioGRID, HPRD10918587 11294897 11350938 11940572 12244095 12576423 12626508 14551213 8626374 details
HCK_HUMANMDM2_HUMANBioGRID25624478 details
HCK_HUMANLMNA_HUMANBioGRID24623722 details
HCK_HUMANP73_HUMANBioGRID17535448 details
HCK_HUMANKRA13_HUMANBioGRID32296183 details
HCK_HUMANERBB2_HUMANBioGRID22973453 details
HCK_HUMANERBB4_HUMANBioGRID22973453 details
HCK_HUMANTMG4_HUMANBioGRID23873930 details
HCK_HUMANAGK_HUMANHPRD16169070 details
HCK_HUMANABL1_HUMANBioGRID, HPRD, MINT10849448 9407116 details
HCK_HUMANDYN2_HUMANHPRD, MINT12029088 details
HCK_HUMANSHIP1_HUMANHPRD, MINT12029088 details
HCK_HUMANSH3K1_HUMANBioGRID, HPRD, MINT12029088 15707590 details
HCK_HUMANHNRPK_HUMANHPRD, MINT12029088 details
HCK_HUMANEVL_HUMANHPRD, MINT12029088 details
HCK_HUMANCD2AP_HUMANHPRD, MINT12029088 details
HCK_HUMAN3BP1_HUMANHPRD, MINT12029088 details
HCK_HUMANTS101_HUMANHPRD, MINT12029088 details
HCK_HUMANWDCP_HUMANHPRD, MINT12029088 details
HCK_HUMANP85B_HUMANHPRD, MINT12029088 details
HCK_HUMANLCP2_HUMANHPRD, MINT12029088 details
HCK_HUMANP85A_HUMANHPRD, MINT12029088 details
HCK_HUMANNUCL_HUMANMINT12029088 details
HCK_HUMANSF3B3_HUMANHPRD, MINT12029088 details
HCK_HUMANRUFY1_HUMANBioGRID, MINT17868192 details
HCK_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
HCK_HUMANPK3CB_HUMANBioGRID, HPRD, IntAct12029088 23397142 25241761 details
HCK_HUMANPLCG1_HUMANHPRD, IntAct10586033 15144186 1689310 23397142 7682059 8657103 8885868 details
HCK_HUMANVGFR1_HUMANIntAct23397142 details
HCK_HUMANCRKL_HUMANIntAct23397142 details
HCK_HUMANADA10_HUMANUniProt25036101 details
HCK_HUMANHS90A_HUMANBioGRID, IntAct22939624 31980649 details
HCK_HUMANCDC37_HUMANBioGRID, IntAct11413142 31980649 details
HCK_HUMANBCR_HUMANBioGRID, HPRD10849448 12522270 12592324 8955135 9178913 9407116 details
HCK_HUMANPECA1_HUMANBioGRID, HPRD10858437 details
HCK_HUMANCCR3_HUMANBioGRID, HPRD10527858 details
HCK_HUMANCHSTF_HUMANBioGRID, HPRD10749872 details
HCK_HUMANIL6RB_HUMANBioGRID, HPRD11689697 details
HCK_HUMANTRPV4_HUMANBioGRID, HPRD12538589 details
HCK_HUMANFCGR1_HUMANBioGRID, HPRD8064233 details
HCK_HUMANSRC_HUMANBioGRID11896602 details
HCK_HUMANACTB_HUMANBioGRID, HPRD12029088 17868192 details
HCK_HUMANFLT3_HUMANBioGRID16684964 details
HCK_HUMANHCK_HUMANBioGRID, HPRD10934191 11976726 31980649 9407116 details
HCK_HUMANVAV_HUMANHPRD9400828 details
HCK_HUMANARRB1_HUMANHPRD10973280 details
HCK_HUMANIL3RB_HUMANHPRD9195918 details
HCK_HUMANCSK_HUMANHPRD11976726 details
HCK_HUMANDOK2_HUMANHPRD10428862 details
HCK_HUMANFCG2A_HUMANHPRD9268059 details
HCK_HUMANUPAR_HUMANHPRD11097855 details
HCK_HUMANPLCG2_HUMANHPRD12181444 15144186 7682059 details
HCK_HUMANI2BPL_HUMANHPRD12029088 details