Entity Details

Primary name RARB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10826
EntryNameRARB_HUMAN
FullNameRetinoic acid receptor beta
TaxID9606
Evidenceevidence at protein level
Length455
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesRARB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001657 ureteric bud development
GO:0002068 glandular epithelial cell development
GO:0003148 outflow tract septum morphogenesis
GO:0003417 growth plate cartilage development
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009755 hormone-mediated signaling pathway
GO:0021756 striatum development
GO:0022008 neurogenesis
GO:0030154 cell differentiation
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0035116 embryonic hindlimb morphogenesis
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048048 embryonic eye morphogenesis
GO:0048384 retinoic acid receptor signaling pathway
GO:0048566 embryonic digestive tract development
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0061351 neural precursor cell proliferation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003078 Retinoic acid receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00459 AcitretinDrugbanksmall molecule
DB00523 AlitretinoinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00799 TazaroteneDrugbanksmall molecule
DB00926 EtretinateDrugbanksmall molecule
DB02877 Arotinoid acidDrugbanksmall molecule
DB04942 TamibaroteneDrugbanksmall molecule
DB05785 LGD-1550Drugbanksmall molecule
DB12808 TrifaroteneDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
RARB_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
RARB_HUMANKPCD2_HUMANBioGRID, MINT15231748 details
RARB_HUMANCCNH_HUMANBioGRID, IntAct21988832 details
RARB_HUMANASXL1_HUMANUniProt16606617 details
RARB_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
RARB_HUMANRXRG_HUMANBioGRID, HPRD, IntAct15604093 20211142 25416956 31515488 32296183 details
RARB_HUMANRXRB_HUMANBioGRID, HPRD, IntAct1331778 15604093 20211142 25416956 26871637 32296183 details
RARB_HUMANPRS8_HUMANBioGRID, IntAct15604093 32296183 details
RARB_HUMANPRGC1_HUMANBioGRID, IntAct32296183 details
RARB_HUMANCCDB1_HUMANBioGRID, IntAct32296183 details
RARB_HUMANHAIR_HUMANBioGRID, IntAct20211142 details
RARB_HUMANGATA3_HUMANBioGRID, IntAct20211142 details
RARB_HUMANNCOA1_HUMANBioGRID, HPRD12665583 15604093 17363140 8754792 details
RARB_HUMANCEBPA_HUMANBioGRID9817600 details
RARB_HUMANCEBPB_HUMANBioGRID9817600 details
RARB_HUMANNCOR2_HUMANBioGRID, HPRD12665583 15604093 details
RARB_HUMANPNRC1_HUMANBioGRID, HPRD15604093 details
RARB_HUMANMAP6_HUMANBioGRID, HPRD15604093 details
RARB_HUMANARI1A_HUMANBioGRID17363140 details
RARB_HUMANSMCE1_HUMANBioGRID17363140 details
RARB_HUMANSMRD3_HUMANBioGRID17363140 details
RARB_HUMANZN423_HUMANIntAct19345331 details
RARB_HUMANRXRA_HUMANBioGRID, HPRD, IntAct15528208 20159610 22022577 7565739 details
RARB_HUMANRARA_HUMANBioGRID, IntAct22022577 28514442 details
RARB_HUMANDISC1_HUMANIntAct31413325 details
RARB_HUMANHACE1_HUMANBioGRID19350571 details
RARB_HUMANGRP75_HUMANBioGRID22022577 details
RARB_HUMANNCOA3_HUMANHPRD12665583 details