Entity Details

Primary name THA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10827
EntryNameTHA_HUMAN
FullNameThyroid hormone receptor alpha
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTHRA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002154 thyroid hormone mediated signaling pathway
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0017025 TBP-class protein binding
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030878 thyroid gland development
GO:0031490 chromatin DNA binding
GO:0033032 regulation of myeloid cell apoptotic process
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050994 regulation of lipid catabolic process
GO:0060509 type I pneumocyte differentiation
GO:0070324 thyroid hormone binding
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000143 negative regulation of DNA-templated transcription, initiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB03176 KB-141Drugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05035 EprotiromeDrugbanksmall molecule
DB05235 NRP409Drugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
THA_HUMANNCOA6_HUMANBioGRID, HPRD, IntAct10567404 10681503 10847592 10866662 11158331 details
THA_HUMANCEP76_HUMANBioGRID, IntAct, MINT21516116 32296183 details
THA_HUMANCLIC1_HUMANBioGRID, IntAct21988832 details
THA_HUMANFOXJ1_HUMANBioGRID, IntAct21988832 details
THA_HUMANBUB3_HUMANBioGRID, IntAct21988832 details
THA_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
THA_HUMANAKP13_HUMANBioGRID, HPRD, UniProt9627117 details
THA_HUMANMED1_HUMANBioGRID, HPRD, UniProt10037764 10733574 11117530 16799563 18391015 21868449 8710870 9653119 details
THA_HUMANTRXR1_HUMANBioGRID, IntAct15199063 details
THA_HUMANLMBL3_HUMANBioGRID, IntAct25416956 details
THA_HUMANAMOL2_HUMANBioGRID, IntAct25416956 32296183 details
THA_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
THA_HUMANSYAP1_HUMANBioGRID, IntAct32296183 details
THA_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
THA_HUMANTACC1_HUMANBioGRID, IntAct32296183 details
THA_HUMANBY55_HUMANBioGRID, IntAct32296183 details
THA_HUMANZBTB3_HUMANIntAct20211142 details
THA_HUMANNRIP1_HUMANBioGRID, IntAct10379889 15130509 20211142 21868449 9626662 details
THA_HUMANTDG_HUMANBioGRID, HPRD12874288 details
THA_HUMANMEF2A_HUMANBioGRID, HPRD12371907 details
THA_HUMAN1433T_HUMANBioGRID11266503 details
THA_HUMANCENPR_HUMANBioGRID10490654 11713274 details
THA_HUMANPO2F1_HUMANBioGRID, HPRD10480874 details
THA_HUMANRT29_HUMANBioGRID10903152 details
THA_HUMANNR0B2_HUMANBioGRID8650544 details
THA_HUMANMED21_HUMANBioGRID, HPRD10198638 15249124 details
THA_HUMANTIF1A_HUMANBioGRID, HPRD31753913 9115274 details
THA_HUMANCSN2_HUMANBioGRID, HPRD10207062 10877839 details
THA_HUMANTRIPB_HUMANBioGRID9256431 details
THA_HUMANRXRA_HUMANBioGRID, HPRD11117530 1314167 1331778 15604093 19422879 details
THA_HUMANFUS_HUMANBioGRID, HPRD9440806 details
THA_HUMANHDAC3_HUMANBioGRID11889044 17242407 details
THA_HUMANNCOR1_HUMANBioGRID, HPRD11889044 15131262 15604093 17242407 7566114 9804773 9849963 details
THA_HUMANSUV91_HUMANBioGRID12138181 details
THA_HUMANNCOA1_HUMANBioGRID, HPRD10379889 11117530 11435616 15140878 15249124 9804773 9849963 details
THA_HUMANNCOA2_HUMANBioGRID11117530 11435616 details
THA_HUMANTAF11_HUMANBioGRID10744685 details
THA_HUMANGRIP1_HUMANBioGRID10379889 9849963 details
THA_HUMANNCOR2_HUMANBioGRID, HPRD16219912 17242407 7566127 9415406 details
THA_HUMANPRKDC_HUMANBioGRID17242407 details
THA_HUMANTBL1X_HUMANBioGRID17242407 details
THA_HUMANCUL1_HUMANBioGRID, HPRD15604093 details
THA_HUMANRGN_HUMANBioGRID, HPRD15604093 details
THA_HUMANSEPP1_HUMANBioGRID15604093 details
THA_HUMANCDK7_HUMANBioGRID, HPRD15249124 details
THA_HUMANMED25_HUMANBioGRID17641689 details
THA_HUMANARI5A_HUMANBioGRID15941852 details
THA_HUMANTF2B_HUMANBioGRID, HPRD7609079 details
THA_HUMANC1D_HUMANBioGRID9405624 details
THA_HUMANTHA_HUMANBioGRID19422879 details
THA_HUMANTEBP_HUMANBioGRID10691735 details
THA_HUMANRANB9_HUMANBioGRID16595702 details
THA_HUMANUBC9_HUMANBioGRID22930759 details
THA_HUMANTRI63_HUMANBioGRID26862156 details
THA_HUMANCREB1_HUMANBioGRID, HPRD12805224 details
THA_HUMANMEOX2_HUMANBioGRID32296183 details
THA_HUMANOASL_HUMANHPRD7776974 details
THA_HUMANESR1_HUMANHPRD9717844 details
THA_HUMANMED17_HUMANBioGRID, IntAct14576168 8710870 details
THA_HUMANP85A_HUMANDIP16966610 details
THA_HUMANCCND1_HUMANBioGRID, HPRD12048199 details
THA_HUMANEP300_HUMANBioGRID12371907 details
THA_HUMANHAIR_HUMANBioGRID11641275 details
THA_HUMANMED12_HUMANBioGRID10198638 8710870 details
THA_HUMANMED16_HUMANBioGRID10198638 8710870 details
THA_HUMANMED6_HUMANBioGRID10198638 details
THA_HUMANMED24_HUMANBioGRID10198638 11117530 8710870 details
THA_HUMANCDK8_HUMANBioGRID10198638 details
THA_HUMANPARP1_HUMANBioGRID15808511 17242407 details
THA_HUMANNCOA3_HUMANBioGRID11117530 details
THA_HUMANTAF7_HUMANBioGRID10409738 details
THA_HUMANEMD_HUMANBioGRID17620012 details
THA_HUMANSMC1A_HUMANBioGRID17242407 details
THA_HUMANDNLI3_HUMANBioGRID17242407 details
THA_HUMANXRCC5_HUMANBioGRID17242407 details
THA_HUMANXRCC6_HUMANBioGRID17242407 details
THA_HUMANHSP74_HUMANBioGRID17242407 details
THA_HUMANTBL1R_HUMANBioGRID17242407 details
THA_HUMANGPS2_HUMANBioGRID17242407 details
THA_HUMANMED14_HUMANBioGRID8710870 details
THA_HUMANTR150_HUMANBioGRID8710870 details
THA_HUMANIMA5_HUMANBioGRID31319097 details
THA_HUMANIMB1_HUMANBioGRID31319097 details
THA_HUMANIPO7_HUMANBioGRID31319097 details
THA_HUMANRXRB_HUMANHPRD1331778 details
THA_HUMANCBP_HUMANHPRD8616895 details
THA_HUMAN1433F_HUMANHPRD11266503 details
THA_HUMANPML_HUMANHPRD10610177 details
THA_HUMANHDAC2_HUMANHPRD10508171 details
THA_HUMANNSD1_HUMANHPRD9628876 details
THA_HUMANBTG1_HUMANHPRD15674337 details
THA_HUMANMOT8_HUMANHPRD12871948 details
THA_HUMANRXRG_HUMANHPRD8127707 details
THA_HUMANSRC_HUMANHPRD15140878 details
THA_HUMANCOT1_HUMANHPRD1331778 details