Entity Details

Primary name GHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10912
EntryNameGHR_HUMAN
FullNameGrowth hormone receptor
TaxID9606
Evidenceevidence at protein level
Length638
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGHR

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004896 cytokine receptor activity
GO:0004903 growth hormone receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006897 endocytosis
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019838 growth factor binding
GO:0019901 protein kinase binding
GO:0019955 cytokine binding
GO:0031623 receptor internalization
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042445 hormone metabolic process
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042976 activation of Janus kinase activity
GO:0043235 receptor complex
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046898 response to cycloheximide
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070064 proline-rich region binding
GO:0070195 growth hormone receptor complex

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR025871 Growth hormone-binding proteinDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00052 SomatotropinDrugbankbiotech
DB00082 PegvisomantDrugbankbiotech
DB09098 SomatremDrugbankbiotech
DB15093 SomapacitanDrugbankbiotech

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
GHR_HUMANNCOA6_HUMANHPRD, IntAct10567404 10866662 details
GHR_HUMANSOMA_HUMANBioGRID, IntAct17500058 24280222 31279174 7862673 8943276 9353194 details
GHR_HUMANPTN2_HUMANBioGRID, HPRD, IntAct12907755 details
GHR_HUMANPTPRB_HUMANBioGRID, IntAct12907755 19167335 details
GHR_HUMANPTN1_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTPRH_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTN9_HUMANBioGRID, IntAct12907755 details
GHR_HUMANPTN3_HUMANBioGRID, IntAct12907755 details
GHR_HUMANDUS7_HUMANBioGRID, IntAct12907755 details
GHR_HUMANCRK_HUMANIntAct17474147 details
GHR_HUMANGRB2_HUMANBioGRID, HPRD, IntAct17474147 9632636 details
GHR_HUMANNCK1_HUMANBioGRID, IntAct17474147 25241761 details
GHR_HUMANP85A_HUMANHPRD, IntAct17474147 9632636 details
GHR_HUMANPLCG1_HUMANBioGRID, IntAct17474147 9632636 details
GHR_HUMANPTPRC_HUMANIntAct19167335 details
GHR_HUMANPTPRK_HUMANIntAct19167335 details
GHR_HUMANPTPRJ_HUMANIntAct19167335 details
GHR_HUMANPTN12_HUMANIntAct19167335 details
GHR_HUMANPTN22_HUMANIntAct19167335 details
GHR_HUMANSTA5B_HUMANBioGRID, HPRD, IntAct25241761 8923468 details
GHR_HUMANGHR_HUMANBioGRID, DIP, HPRD16116438 24280222 8943276 details
GHR_HUMANSGTA_HUMANBioGRID, HPRD12735788 details
GHR_HUMANCISH_HUMANBioGRID, HPRD10585430 12586763 25505247 details
GHR_HUMANSOCS1_HUMANBioGRID, HPRD10585430 details
GHR_HUMANSOCS3_HUMANBioGRID, HPRD10585430 details
GHR_HUMANSOCS2_HUMANBioGRID, HPRD10585430 12135564 16675548 21980433 25505247 28967904 details
GHR_HUMANPTN11_HUMANBioGRID, HPRD10976913 9442080 9632636 details
GHR_HUMANSHC1_HUMANBioGRID, HPRD7535773 9632636 details
GHR_HUMANSTAT3_HUMANBioGRID, HPRD8923468 details
GHR_HUMANFBW1A_HUMANBioGRID17500058 22034227 23607312 details
GHR_HUMANPTN13_HUMANBioGRID12907755 details
GHR_HUMANCHIP_HUMANBioGRID22433856 details
GHR_HUMANSKP1_HUMANBioGRID23607312 25505247 details
GHR_HUMANP85B_HUMANBioGRID9632636 details
GHR_HUMANSRPK2_HUMANBioGRID26167880 details
GHR_HUMANCUL5_HUMANBioGRID25505247 details
GHR_HUMANNEDD8_HUMANBioGRID25505247 details
GHR_HUMANRBX2_HUMANBioGRID25505247 details
GHR_HUMANELOC_HUMANBioGRID25505247 details
GHR_HUMANELOB_HUMANBioGRID25505247 details
GHR_HUMANCUL1_HUMANBioGRID25505247 details
GHR_HUMANFBX31_HUMANBioGRID25505247 details
GHR_HUMANRBX1_HUMANBioGRID25505247 details
GHR_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct25241761 8702683 details
GHR_HUMANJAK2_HUMANBioGRID, HPRD10502458 21347402 24280222 7540178 8063815 details
GHR_HUMANGRB10_HUMANBioGRID, HPRD9632636 details
GHR_HUMANJAK1_HUMANBioGRID, HPRD10502458 details
GHR_HUMANTYK2_HUMANBioGRID, HPRD10502458 details
GHR_HUMANFBW1B_HUMANBioGRID24280222 details
GHR_HUMANIGF1R_HUMANBioGRID15044591 details
GHR_HUMANPTN6_HUMANHPRD9632636 details
GHR_HUMANAP2A1_HUMANHPRD10551776 details
GHR_HUMANIRS1_HUMANHPRD7782332 details
GHR_HUMANSOM2_HUMANHPRD1955498 details