Entity Details

Primary name HGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14210
EntryNameHGF_HUMAN
FullNameHepatocyte growth factor
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHGF

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0000902 cell morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0008083 growth factor activity
GO:0010507 negative regulation of autophagy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030212 hyaluronan metabolic process
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0031100 animal organ regeneration
GO:0031643 positive regulation of myelination
GO:0032715 negative regulation of interleukin-6 production
GO:0032733 positive regulation of interleukin-10 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044877 protein-containing complex binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050673 epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 positive regulation of neuron projection regeneration
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1900744 regulation of p38MAPK cascade
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902947 regulation of tau-protein kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003609 PAN/Apple domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR024174 Hepatocyte growth factor/Macrophage stimulatory proteinFamilyFamily
IPR027284 Hepatocyte growth factorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB02264 O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB03959 N,O6-Disulfo-GlucosamineDrugbanksmall molecule
DB05434 ABT-510Drugbanksmall molecule
DB12307 ForetinibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
HGF_HUMANMET_HUMANBioGRID, DIP, HPRD, IntAct15167892 16537482 1655405 17804794 17981115 1846706 18495663 18593464 19433454 20624990 22897854 28205554 8380735 details
HGF_HUMANHGF_HUMANBioGRID, DIP, HPRD, IntAct11597998 12051906 17804794 20624990 22897854 9817840 9886295 details
HGF_HUMANSRPX2_HUMANIntAct22242148 details
HGF_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
HGF_HUMANATL4_HUMANBioGRID, IntAct25416956 details
HGF_HUMANHGFA_HUMANDIP, HPRD20004165 8631970 details
HGF_HUMANTETN_HUMANBioGRID, HPRD12694198 details
HGF_HUMANSDC2_HUMANBioGRID, HPRD8157651 details
HGF_HUMANSDC1_HUMANBioGRID, HPRD11830493 details
HGF_HUMANBRCA1_HUMANBioGRID25184681 details
HGF_HUMANEPHA2_HUMANBioGRID28205554 details
HGF_HUMANLATS2_HUMANBioGRID28205554 details
HGF_HUMANMYC_HUMANBioGRID28205554 details
HGF_HUMANSTK11_HUMANBioGRID28205554 details
HGF_HUMANMP2K5_HUMANBioGRID28205554 details
HGF_HUMANARNT_HUMANBioGRID28205554 details
HGF_HUMANCCND2_HUMANBioGRID28205554 details
HGF_HUMANCDK4_HUMANBioGRID28205554 details
HGF_HUMANCDK6_HUMANBioGRID28205554 details
HGF_HUMANCDN2A_HUMANBioGRID28205554 details
HGF_HUMANARF_HUMANBioGRID28205554 details
HGF_HUMANCDN2B_HUMANBioGRID28205554 details
HGF_HUMANERBB2_HUMANBioGRID28205554 details
HGF_HUMANFGFR4_HUMANBioGRID28205554 details
HGF_HUMANGLIS2_HUMANBioGRID28205554 details
HGF_HUMANMDM4_HUMANBioGRID28205554 details
HGF_HUMANMERL_HUMANBioGRID28205554 details
HGF_HUMANPGFRA_HUMANBioGRID28205554 details
HGF_HUMANRAF1_HUMANBioGRID28205554 details
HGF_HUMANTEAD2_HUMANBioGRID28205554 details
HGF_HUMANMP2K6_HUMANBioGRID28205554 details
HGF_HUMAN1433G_HUMANBioGRID28205554 details
HGF_HUMANFINC_HUMANBioGRID, HPRD, IntAct15717924 25241761 details
HGF_HUMANHEPS_HUMANHPRD15792801 details
HGF_HUMANUROK_HUMANHPRD1334458 details
HGF_HUMANVTNC_HUMANHPRD15717924 details
HGF_HUMANNGAL_HUMANHPRD15637066 details
HGF_HUMANKLKB1_HUMANHPRD10962009 12372819 details
HGF_HUMANST14_HUMANHPRD10962009 12372819 details
HGF_HUMANFA11_HUMANHPRD10962009 12372819 details